FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2767996512> ?p ?o ?g. }

• W2767996512 endingPage "3217" @default.
• W2767996512 startingPage "3207" @default.
• W2767996512 abstract "Purpose Water homeostasis and transport play important roles in brain function (e.g., ion homeostasis, neuronal excitability, cell volume regulation, etc.). However, specific mechanisms of water transport across cell membranes in neuronal tissue have not been completely elaborated. Methods The kinetics of transcytolemmal water exchange were measured in neuronal tissue using simultaneous, real‐time fluorescence and nuclear magnetic resonance (NMR) measurements of perfused, active brain organotypic cortical cultures. Perfusion with a paramagnetic MRI contrast agent, gadoteridol, allows NMR determination of the unidirectional rate constant for steady‐state cellular water efflux ( k io ), and the mole fraction of intracellular water ( ), related to the average cell volume ( V ). Changes in intracellular calcium concentration were used as a proxy for neuronal activity and were monitored by fluorescence imaging. Results The k io value, averaged over all cultures ( N = 99) at baseline, was 2.02 (±1.72) s −1 , indicating that on average, the equivalent of the entire intracellular water volume turns over twice each second. To probe possible molecular pathways, the specific Na + ‐K + ‐ATPase (NKA) inhibitor, ouabain (1 mM), was transiently introduced into the perfusate. This caused significant transient changes ( N = 8): rose ∼250%, rose ∼89%, and k io fell ∼45%, with a metabolically active k io contribution probably eliminated by ouabain saturation. Conclusions These results suggest that transcytolemmal water exchange in neuronal tissue involves mechanisms affected by NKA activity as well as passive pathways. The active pathway may account for half of the basal homeostatic water flux. Magn Reson Med 79:3207–3217, 2018. © 2017 International Society for Magnetic Resonance in Medicine." @default.
• W2767996512 created "2017-11-17" @default.
• W2767996512 creator A5031674639 @default.
• W2767996512 creator A5038994213 @default.
• W2767996512 creator A5075009651 @default.
• W2767996512 creator A5079843220 @default.
• W2767996512 date "2017-11-06" @default.
• W2767996512 modified "2023-10-14" @default.
• W2767996512 title "Fast, Na⁺/K⁺ pump driven, steady‐state transcytolemmal water exchange in neuronal tissue: A study of rat brain cortical cultures" @default.
• W2767996512 cites W1536289746 @default.
• W2767996512 cites W1570874492 @default.
• W2767996512 cites W1605713159 @default.
• W2767996512 cites W1825279701 @default.
• W2767996512 cites W1912138400 @default.
• W2767996512 cites W1967234887 @default.
• W2767996512 cites W1968698541 @default.
• W2767996512 cites W1975239722 @default.
• W2767996512 cites W1991143420 @default.
• W2767996512 cites W1991506895 @default.
• W2767996512 cites W1995419987 @default.
• W2767996512 cites W1997568797 @default.
• W2767996512 cites W1997574055 @default.
• W2767996512 cites W1998347917 @default.
• W2767996512 cites W2003343999 @default.
• W2767996512 cites W2005538210 @default.
• W2767996512 cites W2009218031 @default.
• W2767996512 cites W2014788725 @default.
• W2767996512 cites W2017676320 @default.
• W2767996512 cites W2022230282 @default.
• W2767996512 cites W2022948281 @default.
• W2767996512 cites W2022989696 @default.
• W2767996512 cites W2023029167 @default.
• W2767996512 cites W2030739181 @default.
• W2767996512 cites W2036722707 @default.
• W2767996512 cites W2048134316 @default.
• W2767996512 cites W2060701169 @default.
• W2767996512 cites W2066674916 @default.
• W2767996512 cites W2066862317 @default.
• W2767996512 cites W2096860121 @default.
• W2767996512 cites W2098237962 @default.
• W2767996512 cites W2106495485 @default.
• W2767996512 cites W2113316687 @default.
• W2767996512 cites W2119906179 @default.
• W2767996512 cites W2124603839 @default.
• W2767996512 cites W2128766971 @default.
• W2767996512 cites W2133612938 @default.
• W2767996512 cites W2141801080 @default.
• W2767996512 cites W2144461176 @default.
• W2767996512 cites W2150148667 @default.
• W2767996512 cites W2159716287 @default.
• W2767996512 cites W2281989312 @default.
• W2767996512 cites W2468050161 @default.
• W2767996512 cites W329559779 @default.
• W2767996512 cites W4231425380 @default.
• W2767996512 doi "https://doi.org/10.1002/mrm.26980" @default.
• W2767996512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29106751" @default.
• W2767996512 hasPublicationYear "2017" @default.
• W2767996512 type Work @default.
• W2767996512 sameAs 2767996512 @default.
• W2767996512 citedByCount "45" @default.
• W2767996512 countsByYear W27679965122018 @default.
• W2767996512 countsByYear W27679965122019 @default.
• W2767996512 countsByYear W27679965122020 @default.
• W2767996512 countsByYear W27679965122021 @default.
• W2767996512 countsByYear W27679965122022 @default.
• W2767996512 countsByYear W27679965122023 @default.
• W2767996512 crossrefType "journal-article" @default.
• W2767996512 hasAuthorship W2767996512A5031674639 @default.
• W2767996512 hasAuthorship W2767996512A5038994213 @default.
• W2767996512 hasAuthorship W2767996512A5075009651 @default.
• W2767996512 hasAuthorship W2767996512A5079843220 @default.
• W2767996512 hasConcept C121332964 @default.
• W2767996512 hasConcept C12554922 @default.
• W2767996512 hasConcept C169760540 @default.
• W2767996512 hasConcept C178790620 @default.
• W2767996512 hasConcept C185592680 @default.
• W2767996512 hasConcept C2779133857 @default.
• W2767996512 hasConcept C28406088 @default.
• W2767996512 hasConcept C46141821 @default.
• W2767996512 hasConcept C537181965 @default.
• W2767996512 hasConcept C55493867 @default.
• W2767996512 hasConcept C63645605 @default.
• W2767996512 hasConcept C74254510 @default.
• W2767996512 hasConcept C79879829 @default.
• W2767996512 hasConcept C86803240 @default.
• W2767996512 hasConcept C95444343 @default.
• W2767996512 hasConceptScore W2767996512C121332964 @default.
• W2767996512 hasConceptScore W2767996512C12554922 @default.
• W2767996512 hasConceptScore W2767996512C169760540 @default.
• W2767996512 hasConceptScore W2767996512C178790620 @default.
• W2767996512 hasConceptScore W2767996512C185592680 @default.
• W2767996512 hasConceptScore W2767996512C2779133857 @default.
• W2767996512 hasConceptScore W2767996512C28406088 @default.
• W2767996512 hasConceptScore W2767996512C46141821 @default.
• W2767996512 hasConceptScore W2767996512C537181965 @default.
• W2767996512 hasConceptScore W2767996512C55493867 @default.
• W2767996512 hasConceptScore W2767996512C63645605 @default.
• W2767996512 hasConceptScore W2767996512C74254510 @default.

• next