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• W2768030282 abstract "Virulence evolution may have far-reaching consequences for virus epidemiology and emergence, and virologists have devoted increasing effort to understand the modulators of this process. However, still little is known on the mechanisms and determinants of virulence evolution in sterilizing viruses that, as they prevent host reproduction, may have devastating effects on host populations. Theory predicts that sterilizing parasites, including viruses, would evolve towards lower virulence and absolute host sterilization to optimize the exploitation of host resources and maximize fitness. However, this hypothesis has seldom been analyzed experimentally. We investigated the evolution of virulence of the sterilizing plant virus Turnip mosaic virus (TuMV) in its natural host Arabidopsis thaliana by serial passage experiments. After passaging, we quantified virus accumulation and infectivity, the effect of infection on plant growth and development, and virulence of the ancestral and passaged viral genotypes in A. thaliana. Results indicated that serial passaging increased the proportion of infected plants showing absolute sterility, reduced TuMV virulence, and increased virus multiplication and infectivity. Genomic comparison of the ancestral and passaged TuMV genotypes identified significant mutation clustering in the P1, P3, and 6K2 proteins, suggesting a role of these viral proteins in the observed phenotypic changes. Our results support theoretical predictions on the evolution of virulence of sterilizing parasites and contribute to better understand the phenotypic and genetic changes associated with this process." @default.
• W2768030282 created "2017-11-17" @default.
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• W2768030282 date "2017-07-01" @default.
• W2768030282 modified "2023-09-24" @default.
• W2768030282 title "Virulence evolution of a sterilizing plant virus: Tuning multiplication and resource exploitation" @default.
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• W2768030282 doi "https://doi.org/10.1093/ve/vex033" @default.
• W2768030282 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5724401" @default.
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• W2768030282 hasPublicationYear "2017" @default.
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