FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768087199> ?p ?o ?g. }

• W2768087199 endingPage "4553" @default.
• W2768087199 startingPage "4541" @default.
• W2768087199 abstract "Food allergy occurs due to IgE- and mast cell-dependent intestinal inflammation. Previously, we showed that histamine-releasing factor (HRF), a multifunctional protein secreted during allergy, interacts with a subset of IgE molecules and that the HRF dimer activates mast cells in an HRF-reactive IgE-dependent manner. In this study, we investigated whether HRF plays any role in food allergy. Specifically, we determined that prophylactic and therapeutic administration of HRF inhibitors that block HRF-IgE interactions reduces the incidence of diarrhea and mastocytosis in a murine model of food allergy. Food allergy-associated intestinal inflammation was accompanied by increased secretion of the HRF dimer into the intestine in response to proinflammatory, Th2, and epithelial-derived cytokines and HRF-reactive IgE levels at the elicitation phase. Consistent with these data, patients with egg allergy had higher blood levels of HRF-reactive IgE compared with individuals that were not hypersensitive. Successful oral immunotherapy in egg-allergy patients and food-allergic mice reduced HRF-reactive IgE levels, thereby suggesting a pathological role for HRF in food allergy. Together, these results suggest that antigen and HRF dimer amplify intestinal inflammation by synergistically activating mast cells and indicate that HRF has potential as a therapeutic target in food allergy." @default.
• W2768087199 created "2017-11-17" @default.
• W2768087199 creator A5011954268 @default.
• W2768087199 creator A5017568080 @default.
• W2768087199 creator A5017703782 @default.
• W2768087199 creator A5020420006 @default.
• W2768087199 creator A5022419570 @default.
• W2768087199 creator A5030787345 @default.
• W2768087199 creator A5036068133 @default.
• W2768087199 creator A5039402819 @default.
• W2768087199 creator A5044502423 @default.
• W2768087199 creator A5048781927 @default.
• W2768087199 creator A5050803031 @default.
• W2768087199 creator A5062741202 @default.
• W2768087199 creator A5063906321 @default.
• W2768087199 creator A5065047534 @default.
• W2768087199 creator A5068044071 @default.
• W2768087199 creator A5077189198 @default.
• W2768087199 date "2017-11-13" @default.
• W2768087199 modified "2023-10-16" @default.
• W2768087199 title "Histamine-releasing factor enhances food allergy" @default.
• W2768087199 cites W1529005412 @default.
• W2768087199 cites W1531385164 @default.
• W2768087199 cites W1604469913 @default.
• W2768087199 cites W1950566404 @default.
• W2768087199 cites W1959193977 @default.
• W2768087199 cites W1965086572 @default.
• W2768087199 cites W1967694717 @default.
• W2768087199 cites W1972388214 @default.
• W2768087199 cites W1973792501 @default.
• W2768087199 cites W1981034102 @default.
• W2768087199 cites W1993624559 @default.
• W2768087199 cites W1993734178 @default.
• W2768087199 cites W2012288686 @default.
• W2768087199 cites W2016914968 @default.
• W2768087199 cites W2024979136 @default.
• W2768087199 cites W2027783756 @default.
• W2768087199 cites W2032634575 @default.
• W2768087199 cites W2048684418 @default.
• W2768087199 cites W2049011893 @default.
• W2768087199 cites W2057280876 @default.
• W2768087199 cites W2058065781 @default.
• W2768087199 cites W2069780509 @default.
• W2768087199 cites W2080229642 @default.
• W2768087199 cites W2086874669 @default.
• W2768087199 cites W2093680901 @default.
• W2768087199 cites W2095745982 @default.
• W2768087199 cites W2098057841 @default.
• W2768087199 cites W2107074680 @default.
• W2768087199 cites W2108935540 @default.
• W2768087199 cites W2109383966 @default.
• W2768087199 cites W2117748999 @default.
• W2768087199 cites W2120948675 @default.
• W2768087199 cites W2130633620 @default.
• W2768087199 cites W2152058975 @default.
• W2768087199 cites W2157118802 @default.
• W2768087199 cites W2159865326 @default.
• W2768087199 cites W2169785267 @default.
• W2768087199 cites W2318264742 @default.
• W2768087199 cites W2326183777 @default.
• W2768087199 cites W2461747480 @default.
• W2768087199 cites W2545836320 @default.
• W2768087199 cites W2549971052 @default.
• W2768087199 cites W2740763275 @default.
• W2768087199 cites W3022011172 @default.
• W2768087199 cites W4238655274 @default.
• W2768087199 doi "https://doi.org/10.1172/jci96525" @default.
• W2768087199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5707161" @default.
• W2768087199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29130935" @default.
• W2768087199 hasPublicationYear "2017" @default.
• W2768087199 type Work @default.
• W2768087199 sameAs 2768087199 @default.
• W2768087199 citedByCount "32" @default.
• W2768087199 countsByYear W27680871992017 @default.
• W2768087199 countsByYear W27680871992018 @default.
• W2768087199 countsByYear W27680871992019 @default.
• W2768087199 countsByYear W27680871992020 @default.
• W2768087199 countsByYear W27680871992021 @default.
• W2768087199 countsByYear W27680871992022 @default.
• W2768087199 countsByYear W27680871992023 @default.
• W2768087199 crossrefType "journal-article" @default.
• W2768087199 hasAuthorship W2768087199A5011954268 @default.
• W2768087199 hasAuthorship W2768087199A5017568080 @default.
• W2768087199 hasAuthorship W2768087199A5017703782 @default.
• W2768087199 hasAuthorship W2768087199A5020420006 @default.
• W2768087199 hasAuthorship W2768087199A5022419570 @default.
• W2768087199 hasAuthorship W2768087199A5030787345 @default.
• W2768087199 hasAuthorship W2768087199A5036068133 @default.
• W2768087199 hasAuthorship W2768087199A5039402819 @default.
• W2768087199 hasAuthorship W2768087199A5044502423 @default.
• W2768087199 hasAuthorship W2768087199A5048781927 @default.
• W2768087199 hasAuthorship W2768087199A5050803031 @default.
• W2768087199 hasAuthorship W2768087199A5062741202 @default.
• W2768087199 hasAuthorship W2768087199A5063906321 @default.
• W2768087199 hasAuthorship W2768087199A5065047534 @default.
• W2768087199 hasAuthorship W2768087199A5068044071 @default.
• W2768087199 hasAuthorship W2768087199A5077189198 @default.
• W2768087199 hasBestOaLocation W27680871991 @default.

• next