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- W2768093345 abstract "Significance EmrE facilitates Escherichia coli multidrug resistance by coupling drug efflux to proton import. This antiport mechanism has been thought to occur via a pure-exchange model, which achieves coupled antiport by restricting when the single binding pocket can alternate access between opposite sides of the membrane. We test this model using NMR titrations and transport assays and find it cannot account for EmrE antiport activity. We propose a new free-exchange model of antiport with fewer restrictions that better accounts for the highly promiscuous nature of EmrE drug efflux. This model expands our understanding of proton-coupled transport and has implications for both transporter design and drug development." @default.
- W2768093345 created "2017-11-17" @default.
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- W2768093345 date "2017-11-07" @default.
- W2768093345 modified "2023-10-14" @default.
- W2768093345 title "New free-exchange model of EmrE transport" @default.
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- W2768093345 doi "https://doi.org/10.1073/pnas.1708671114" @default.
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