FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768093454> ?p ?o ?g. }

• W2768093454 abstract "Chronic metabolic acidosis (CMA) refers to increased plasma acidity due to disturbed acid-base equilibrium in human body. CMA leads to many dysfunctions including disorders of intestinal metabolism and barrier functions. The human body responds to these intestinal dysfunctions by creating a compensatory mechanism at genomic level in intestinal epithelial cells. This study was to identify the molecular pathways involved in metabolic dysfunction and compensatory adaptations in intestinal epithelium during CMA.In silico approaches were utilized to characterize a set of 88 differentially expressed genes (DEGs) from intestinal cells of rat CMA model. Interaction networks were constructed for DEGs by GeneMANIA and hub genes as well as enriched clusters in the network were screened using GLay. Gene Ontology (GO) was used for enriching functions in each cluster.Four gene hubs, i.e., trefoil factor 1, 5-hydroxytryptamine (serotonin) receptor 5a, solute carrier family 6 (neurotransmitter transporter), member 11, and glutamate receptor, ionotropic, n-methyl d-aspartate 2b, exhibiting the highest node degree were predicted. Six biologically related gene clusters were also predicted. Functional enrichment of GO terms predicted neurological processes such as neurological system process regulation and nerve impulse transmission which are related to negative and positive regulation of digestive system processes., intestinal motility and absorption and maintenance of gastrointestinal epithelium.The study predicted several important genomic pathways that potentially play significant roles in metabolic disruptions or compensatory adaptations of intestinal epithelium induced by CMA. The results provide a further insight into underlying molecular mechanisms associated with CMA." @default.
• W2768093454 created "2017-11-17" @default.
• W2768093454 creator A5032796483 @default.
• W2768093454 creator A5033224629 @default.
• W2768093454 creator A5042243661 @default.
• W2768093454 creator A5080173309 @default.
• W2768093454 date "2018-01-01" @default.
• W2768093454 modified "2023-09-24" @default.
• W2768093454 title "In silico identification of genes involved in chronic metabolic acidosis" @default.
• W2768093454 cites W1009704129 @default.
• W2768093454 cites W1175948956 @default.
• W2768093454 cites W1561206275 @default.
• W2768093454 cites W1805084076 @default.
• W2768093454 cites W1897929089 @default.
• W2768093454 cites W1967851000 @default.
• W2768093454 cites W1968794790 @default.
• W2768093454 cites W1972449270 @default.
• W2768093454 cites W1978559408 @default.
• W2768093454 cites W1980792788 @default.
• W2768093454 cites W1981126790 @default.
• W2768093454 cites W1985213868 @default.
• W2768093454 cites W1988731737 @default.
• W2768093454 cites W1989921625 @default.
• W2768093454 cites W1997778906 @default.
• W2768093454 cites W1999580771 @default.
• W2768093454 cites W2000295875 @default.
• W2768093454 cites W2031325230 @default.
• W2768093454 cites W2033431994 @default.
• W2768093454 cites W2042516086 @default.
• W2768093454 cites W2048164032 @default.
• W2768093454 cites W2063570717 @default.
• W2768093454 cites W2065249304 @default.
• W2768093454 cites W2066168019 @default.
• W2768093454 cites W2067794232 @default.
• W2768093454 cites W2076509340 @default.
• W2768093454 cites W2081451983 @default.
• W2768093454 cites W2090419595 @default.
• W2768093454 cites W2094250752 @default.
• W2768093454 cites W2106659946 @default.
• W2768093454 cites W2112215250 @default.
• W2768093454 cites W2119844942 @default.
• W2768093454 cites W2123363819 @default.
• W2768093454 cites W2136063757 @default.
• W2768093454 cites W2142341955 @default.
• W2768093454 cites W2153718909 @default.
• W2768093454 cites W2153879315 @default.
• W2768093454 cites W2155142785 @default.
• W2768093454 cites W2165891030 @default.
• W2768093454 cites W2285111936 @default.
• W2768093454 cites W2395493973 @default.
• W2768093454 cites W2409219857 @default.
• W2768093454 cites W282647877 @default.
• W2768093454 doi "https://doi.org/10.1016/j.lfs.2017.11.014" @default.
• W2768093454 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29138116" @default.
• W2768093454 hasPublicationYear "2018" @default.
• W2768093454 type Work @default.
• W2768093454 sameAs 2768093454 @default.
• W2768093454 citedByCount "0" @default.
• W2768093454 crossrefType "journal-article" @default.
• W2768093454 hasAuthorship W2768093454A5032796483 @default.
• W2768093454 hasAuthorship W2768093454A5033224629 @default.
• W2768093454 hasAuthorship W2768093454A5042243661 @default.
• W2768093454 hasAuthorship W2768093454A5080173309 @default.
• W2768093454 hasConcept C104317684 @default.
• W2768093454 hasConcept C115955781 @default.
• W2768093454 hasConcept C134018914 @default.
• W2768093454 hasConcept C149011108 @default.
• W2768093454 hasConcept C168785527 @default.
• W2768093454 hasConcept C170493617 @default.
• W2768093454 hasConcept C2775905019 @default.
• W2768093454 hasConcept C54355233 @default.
• W2768093454 hasConcept C61174792 @default.
• W2768093454 hasConcept C62231903 @default.
• W2768093454 hasConcept C86803240 @default.
• W2768093454 hasConcept C95444343 @default.
• W2768093454 hasConcept C96942376 @default.
• W2768093454 hasConceptScore W2768093454C104317684 @default.
• W2768093454 hasConceptScore W2768093454C115955781 @default.
• W2768093454 hasConceptScore W2768093454C134018914 @default.
• W2768093454 hasConceptScore W2768093454C149011108 @default.
• W2768093454 hasConceptScore W2768093454C168785527 @default.
• W2768093454 hasConceptScore W2768093454C170493617 @default.
• W2768093454 hasConceptScore W2768093454C2775905019 @default.
• W2768093454 hasConceptScore W2768093454C54355233 @default.
• W2768093454 hasConceptScore W2768093454C61174792 @default.
• W2768093454 hasConceptScore W2768093454C62231903 @default.
• W2768093454 hasConceptScore W2768093454C86803240 @default.
• W2768093454 hasConceptScore W2768093454C95444343 @default.
• W2768093454 hasConceptScore W2768093454C96942376 @default.
• W2768093454 hasFunder F4320322322 @default.
• W2768093454 hasFunder F4320335726 @default.
• W2768093454 hasLocation W27680934541 @default.
• W2768093454 hasLocation W27680934542 @default.
• W2768093454 hasOpenAccess W2768093454 @default.
• W2768093454 hasPrimaryLocation W27680934541 @default.
• W2768093454 hasRelatedWork W1828691184 @default.
• W2768093454 hasRelatedWork W2001677368 @default.
• W2768093454 hasRelatedWork W2002128513 @default.
• W2768093454 hasRelatedWork W2067565468 @default.
• W2768093454 hasRelatedWork W2085192631 @default.

• next