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• W2768115893 abstract "Summary This study was designed to investigate the possible synergism of amlodipine and candesartan on the reduction of blood pressure ( BP ) in hypertensive rats. The end organ protection was also observed. In acute experiment, spontaneously hypertensive rats ( SHR s) were treated with intragastric administration of amlodipine (0.5, 1, 2, 3 mg/kg), candesartan (1, 2, 3, 4, 6, 8 mg/kg), and 14 different combinations to find the possible ratio of synergistic interaction. In two kidneys, one clip (2K1C) rats, the effects of amlodipine (1 mg/kg), canderastan (2 mg/kg) and their combination on BP reduction were also observed. In chronic study, SHR s were treated with amlodipine (1 mg/kg), candesartan (2 mg/kg), and their combination for 5 months. Organ damage evaluation was performed after BP recording. The probability sum test ( q test) was used to evaluate the synergistic action. There is a synergistic interaction between amlodipine and candesartan on BP reduction. The optimal dose ratio is 1:2. The synergistic effect was also confirmed by 2K1C hypertensive rats. In chronic study, this combination (1:2) possessed an obvious synergism on the reduction of BP and BP variability ( BPV ) and protection on end organs. Multiple regression analysis showed that heart and aortic hypertrophy indexes and glomerular damage parameters were positively related to BP and BPV . In conclusion, combination of amlodipine and candesartan exhibited a potent antihypertensive effect and possessed an obvious synergism on BP reduction and organ protection in hypertension. The optimal proportion was 1:2. BP and BPV reduction may both importantly contribute to end organ protection." @default.
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• W2768115893 date "2018-01-16" @default.
• W2768115893 modified "2023-10-14" @default.
• W2768115893 title "Synergism of amlodipine and candesartan on blood pressure reduction and organ protection in hypertensive rats" @default.
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• W2768115893 doi "https://doi.org/10.1111/1440-1681.12901" @default.
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