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- W2768193816 abstract "Pathophysiological changes affecting drugpharmacokineticsMortality due to severe infections in the intensive careunit (ICU) remains high despite recent therapeuticadvancements [1]. However, appropriate antibiotic administration(including spectrum of activity and therapeuticexposure) is rarely a straightforward process in ICUpatients as they commonly develop extreme pathophysiologicalchanges that can alter antibiotic pharmacokineticsand consequently affect drug exposure in this population.The volume of distribution and drug clearance are thepharmacokinetic parameters of greatest relevance to determiningdrug dosing requirements, and both parametersmay be significantly deranged during critical illness [2, 3].Furthermore, ICU pathogens are relatively different fromthose in the general wards as they commonly havereduced antibiotic susceptibility [4]. Despite profoundphysiological and pharmacokinetic differences to the noncriticallyill population, critically ill patients are typicallygiven conventional antibiotic dosing regimens, which increasethe likelihood of therapeutic failures and the emergenceof bacterial resistance [5]." @default.
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- W2768193816 date "2017-11-21" @default.
- W2768193816 modified "2023-10-12" @default.
- W2768193816 title "Identifying “at-risk” patients for sub-optimal beta-lactam exposure in critically ill patients with severe infections" @default.
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- W2768193816 doi "https://doi.org/10.1186/s13054-017-1871-2" @default.
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