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- W2768194674 endingPage "36" @default.
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- W2768194674 abstract "Numerous phase III studies of glucagon-like peptide 1 (GLP-1) analogue liraglutide, recently licensed by the Food and Drug Administration and European Medical Association for the medical management of obese and comorbidly overweight individuals, at a high dose (3 mg/day) have repeatedly demonstrated a superior achievement and maintained weight loss in obese individuals compared with placebo control and currently licensed antiobesity medications.Although the pathophysiology of human obesity is undoubtedly multifaceted, clinical evidence implicates a role for altered GLP-1 signaling; genetic studies suggest altered GLP-1 signaling to be a risk factor toward obesity, whereas observational and interventional studies of GLP-1 responses in lean and obese men suggest that weight gain may induce secondary deficits in GLP-1. Whatever the relationship, cause, or effect, functional GLP-1 signaling seems to play a role in obesity pathophysiology: pharmacologic replenishment of this deficit perhaps explains the superior weight loss profile of GLP-1 agonists as weight loss agents. Generally well tolerated, provided that longer-term postmarketing surveillance supports the currently available evidence of a low risk-benefit ratio, GLP-1 analogues provide promise toward achieving the as-yet unmet clinical need for a successful sustainable drug for the medical management of obesity." @default.
- W2768194674 created "2017-12-04" @default.
- W2768194674 creator A5017519053 @default.
- W2768194674 creator A5046318909 @default.
- W2768194674 date "2018-01-01" @default.
- W2768194674 modified "2023-10-16" @default.
- W2768194674 title "Glucagon-Like Peptide 1 and Human Obesity" @default.
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