Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768221082> ?p ?o ?g. }
- W2768221082 endingPage "14" @default.
- W2768221082 startingPage "7" @default.
- W2768221082 abstract "Determination of appropriate chamber size is critical for normal vertebrate heart development. Although Nr2f transcription factors promote atrial maintenance and differentiation, how they determine atrial size remains unclear. Here, we demonstrate that zebrafish Nr2f1a is expressed in differentiating atrial cardiomyocytes. Zebrafish nr2f1a mutants have smaller atria due to a specific reduction in atrial cardiomyocyte (AC) number, suggesting it has similar requirements to Nr2f2 in mammals. Furthermore, the smaller atria in nr2f1a mutants are derived from distinct mechanisms that perturb AC differentiation at the chamber poles. At the venous pole, Nr2f1a enhances the rate of AC differentiation. Nr2f1a also establishes the atrial-atrioventricular canal (AVC) border through promoting the differentiation of mature ACs. Without Nr2f1a, AVC markers are expanded into the atrium, resulting in enlarged endocardial cushions (ECs). Inhibition of Bmp signaling can restore EC development, but not AC number, suggesting that Nr2f1a concomitantly coordinates atrial and AVC size through both Bmp-dependent and independent mechanisms. These findings provide insight into conserved functions of Nr2f proteins and the etiology of atrioventricular septal defects (AVSDs) associated with NR2F2 mutations in humans." @default.
- W2768221082 created "2017-12-04" @default.
- W2768221082 creator A5031465348 @default.
- W2768221082 creator A5049983113 @default.
- W2768221082 creator A5057524880 @default.
- W2768221082 creator A5063561762 @default.
- W2768221082 creator A5075155337 @default.
- W2768221082 creator A5075385072 @default.
- W2768221082 creator A5086227409 @default.
- W2768221082 creator A5089357296 @default.
- W2768221082 creator A5091779911 @default.
- W2768221082 date "2018-02-01" @default.
- W2768221082 modified "2023-10-17" @default.
- W2768221082 title "Nr2f1a balances atrial chamber and atrioventricular canal size via BMP signaling-independent and -dependent mechanisms" @default.
- W2768221082 cites W1973449157 @default.
- W2768221082 cites W1987155219 @default.
- W2768221082 cites W1996337584 @default.
- W2768221082 cites W1996951529 @default.
- W2768221082 cites W1998342517 @default.
- W2768221082 cites W2000779896 @default.
- W2768221082 cites W2003959047 @default.
- W2768221082 cites W2008553597 @default.
- W2768221082 cites W2009516278 @default.
- W2768221082 cites W2010655878 @default.
- W2768221082 cites W2011190652 @default.
- W2768221082 cites W2017224987 @default.
- W2768221082 cites W2024353183 @default.
- W2768221082 cites W2030516373 @default.
- W2768221082 cites W2032382800 @default.
- W2768221082 cites W2038600043 @default.
- W2768221082 cites W2039801978 @default.
- W2768221082 cites W2040686597 @default.
- W2768221082 cites W2052526766 @default.
- W2768221082 cites W2061184966 @default.
- W2768221082 cites W2062558128 @default.
- W2768221082 cites W2065462886 @default.
- W2768221082 cites W2070779001 @default.
- W2768221082 cites W2073187339 @default.
- W2768221082 cites W2081558031 @default.
- W2768221082 cites W2082152178 @default.
- W2768221082 cites W2086054284 @default.
- W2768221082 cites W2088825224 @default.
- W2768221082 cites W2097294303 @default.
- W2768221082 cites W2099540110 @default.
- W2768221082 cites W2100483634 @default.
- W2768221082 cites W2101816987 @default.
- W2768221082 cites W2103923249 @default.
- W2768221082 cites W2105902283 @default.
- W2768221082 cites W2110997400 @default.
- W2768221082 cites W2112567404 @default.
- W2768221082 cites W2120328369 @default.
- W2768221082 cites W2124752518 @default.
- W2768221082 cites W2124959222 @default.
- W2768221082 cites W2137562589 @default.
- W2768221082 cites W2139456654 @default.
- W2768221082 cites W2152387100 @default.
- W2768221082 cites W2153361555 @default.
- W2768221082 cites W2159534153 @default.
- W2768221082 cites W2159561432 @default.
- W2768221082 cites W2161121464 @default.
- W2768221082 cites W2162277712 @default.
- W2768221082 cites W2164386538 @default.
- W2768221082 cites W2165088108 @default.
- W2768221082 cites W2285741280 @default.
- W2768221082 cites W2297974985 @default.
- W2768221082 cites W2555626725 @default.
- W2768221082 cites W2556548281 @default.
- W2768221082 cites W2557927839 @default.
- W2768221082 cites W2590671119 @default.
- W2768221082 cites W822351282 @default.
- W2768221082 doi "https://doi.org/10.1016/j.ydbio.2017.11.010" @default.
- W2768221082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5785549" @default.
- W2768221082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29157563" @default.
- W2768221082 hasPublicationYear "2018" @default.
- W2768221082 type Work @default.
- W2768221082 sameAs 2768221082 @default.
- W2768221082 citedByCount "21" @default.
- W2768221082 countsByYear W27682210822018 @default.
- W2768221082 countsByYear W27682210822019 @default.
- W2768221082 countsByYear W27682210822020 @default.
- W2768221082 countsByYear W27682210822021 @default.
- W2768221082 countsByYear W27682210822022 @default.
- W2768221082 countsByYear W27682210822023 @default.
- W2768221082 crossrefType "journal-article" @default.
- W2768221082 hasAuthorship W2768221082A5031465348 @default.
- W2768221082 hasAuthorship W2768221082A5049983113 @default.
- W2768221082 hasAuthorship W2768221082A5057524880 @default.
- W2768221082 hasAuthorship W2768221082A5063561762 @default.
- W2768221082 hasAuthorship W2768221082A5075155337 @default.
- W2768221082 hasAuthorship W2768221082A5075385072 @default.
- W2768221082 hasAuthorship W2768221082A5086227409 @default.
- W2768221082 hasAuthorship W2768221082A5089357296 @default.
- W2768221082 hasAuthorship W2768221082A5091779911 @default.
- W2768221082 hasBestOaLocation W27682210822 @default.
- W2768221082 hasConcept C104317684 @default.
- W2768221082 hasConcept C105702510 @default.
- W2768221082 hasConcept C114021368 @default.
- W2768221082 hasConcept C126322002 @default.