Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768238915> ?p ?o ?g. }
- W2768238915 endingPage "345" @default.
- W2768238915 startingPage "330" @default.
- W2768238915 abstract "Mendelian randomization (MR) is a strategy for evaluating causality in observational epidemiological studies. MR exploits the fact that genotypes are not generally susceptible to reverse causation and confounding, due to their fixed nature and Mendel's First and Second Laws of Inheritance. MR has the potential to provide information on causality in many situations where randomized controlled trials are not possible, but the results of MR studies must be interpreted carefully to avoid drawing erroneous conclusions.In this review, we outline the principles behind MR, as well as assumptions and limitations of the method. Extensions to the basic approach are discussed, including two-sample MR, bidirectional MR, two-step MR, multivariable MR, and factorial MR. We also consider some new applications and recent developments in the methodology, including its ability to inform drug development, automation of the method using tools such as MR-Base, and phenome-wide and hypothesis-free MR.In conjunction with the growing availability of large-scale genomic databases, higher level of automation and increased robustness of the methods, MR promises to be a valuable strategy to examine causality in complex biological/omics networks, inform drug development and prioritize intervention targets for disease prevention in the future." @default.
- W2768238915 created "2017-12-04" @default.
- W2768238915 creator A5000627023 @default.
- W2768238915 creator A5013184354 @default.
- W2768238915 creator A5016515762 @default.
- W2768238915 creator A5049890184 @default.
- W2768238915 creator A5058920702 @default.
- W2768238915 creator A5063266547 @default.
- W2768238915 creator A5068924232 @default.
- W2768238915 creator A5072701813 @default.
- W2768238915 date "2017-11-22" @default.
- W2768238915 modified "2023-10-10" @default.
- W2768238915 title "Recent Developments in Mendelian Randomization Studies" @default.
- W2768238915 cites W1596038729 @default.
- W2768238915 cites W1604069670 @default.
- W2768238915 cites W1902575419 @default.
- W2768238915 cites W1905058580 @default.
- W2768238915 cites W1972696558 @default.
- W2768238915 cites W1983259675 @default.
- W2768238915 cites W1983321056 @default.
- W2768238915 cites W1997338841 @default.
- W2768238915 cites W2046181127 @default.
- W2768238915 cites W2048760408 @default.
- W2768238915 cites W2052518513 @default.
- W2768238915 cites W2058224718 @default.
- W2768238915 cites W2067539811 @default.
- W2768238915 cites W2081615427 @default.
- W2768238915 cites W2082704080 @default.
- W2768238915 cites W2097040757 @default.
- W2768238915 cites W2097510503 @default.
- W2768238915 cites W2099817335 @default.
- W2768238915 cites W2102309722 @default.
- W2768238915 cites W2103783427 @default.
- W2768238915 cites W2104895625 @default.
- W2768238915 cites W2105079646 @default.
- W2768238915 cites W2106036991 @default.
- W2768238915 cites W2109003937 @default.
- W2768238915 cites W2111735528 @default.
- W2768238915 cites W2113699335 @default.
- W2768238915 cites W2118008714 @default.
- W2768238915 cites W2118743532 @default.
- W2768238915 cites W2118825330 @default.
- W2768238915 cites W2121514846 @default.
- W2768238915 cites W2128736149 @default.
- W2768238915 cites W2135255861 @default.
- W2768238915 cites W2138842039 @default.
- W2768238915 cites W2139875520 @default.
- W2768238915 cites W2143727405 @default.
- W2768238915 cites W2147841289 @default.
- W2768238915 cites W2147882394 @default.
- W2768238915 cites W2147943581 @default.
- W2768238915 cites W2151034010 @default.
- W2768238915 cites W2152795085 @default.
- W2768238915 cites W2153118028 @default.
- W2768238915 cites W2154882438 @default.
- W2768238915 cites W2159738130 @default.
- W2768238915 cites W2163969089 @default.
- W2768238915 cites W2166082348 @default.
- W2768238915 cites W2169283889 @default.
- W2768238915 cites W2195783463 @default.
- W2768238915 cites W2237597923 @default.
- W2768238915 cites W2243398804 @default.
- W2768238915 cites W2292311686 @default.
- W2768238915 cites W2295447825 @default.
- W2768238915 cites W2296625401 @default.
- W2768238915 cites W2298141847 @default.
- W2768238915 cites W2314452539 @default.
- W2768238915 cites W2324387650 @default.
- W2768238915 cites W2324862792 @default.
- W2768238915 cites W2325761966 @default.
- W2768238915 cites W2328393125 @default.
- W2768238915 cites W2345621280 @default.
- W2768238915 cites W2395244354 @default.
- W2768238915 cites W2398690791 @default.
- W2768238915 cites W2402301293 @default.
- W2768238915 cites W2475125285 @default.
- W2768238915 cites W2478496979 @default.
- W2768238915 cites W2481252033 @default.
- W2768238915 cites W2508534964 @default.
- W2768238915 cites W2510387549 @default.
- W2768238915 cites W2519140039 @default.
- W2768238915 cites W2528374605 @default.
- W2768238915 cites W2550031966 @default.
- W2768238915 cites W2557654447 @default.
- W2768238915 cites W2559592043 @default.
- W2768238915 cites W2581245397 @default.
- W2768238915 cites W2582094868 @default.
- W2768238915 cites W2588618729 @default.
- W2768238915 cites W2590777827 @default.
- W2768238915 cites W2592294322 @default.
- W2768238915 cites W2593125540 @default.
- W2768238915 cites W2597850678 @default.
- W2768238915 cites W2604218568 @default.
- W2768238915 cites W2610574085 @default.
- W2768238915 cites W2618437585 @default.
- W2768238915 cites W2620908531 @default.
- W2768238915 cites W2724817460 @default.
- W2768238915 cites W2727486917 @default.