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• W2768244927 abstract "Hydrogen sulfide (H2S) is an endogenously produced neuroactive gas implicated in many key processes in the peripheral and central nervous system. Whereas the neuroprotective role of H2S has been shown in adult brain, the action of this messenger in newborns remains unclear. One of the known targets of H2S in the nervous system is the N-methyl-D-aspartate (NMDA) glutamate receptor which can be composed of different subunits with distinct functional properties. In the present study, using patch clamp technique, we compared the effects of the H2S donor sodium hydrosulfide (NaHS, 100 µM) on hippocampal NMDA receptor mediated currents in rats of the first and third postnatal weeks. This was supplemented by testing effects of NaHS on recombinant GluN1/2A and GluN1/2B NMDA receptors expressed in HEK293T cells. The main finding is that NaHS action on NMDA currents is age-dependent. Currents were reduced in newborns but increased in older juvenile rats. Consistent with an age-dependent switch in NMDA receptor composition, in HEK239T cells expressing GluN1/2A receptors, NaHS increased NMDA activated currents associated with acceleration of desensitization and decrease of the deactivation rate. In contrast, in GluN1/2B NMDA receptors, which are prevalent in newborns, NaHS decreased currents and reduced receptor deactivation without effect on the desensitization rate. Adenylate cyclase inhibitor MDL-12330A (10 µM) did not prevent the age-dependent effects of NaHS on NMDA-evoked currents in pyramidal neurons of hippocampus. The reducing agent dithiothreitol (2 mM) applied on HEK293T cells prevented facilitation induced by NaHS on GluN1/2A NMDA receptors, however in GluN1/2B NMDA receptors the inhibitory effect of NaHS was still observed. Our data indicate age-dependent effect of H2S on NMDA receptor mediated currents determined by glutamate receptor subunit composition. While the inhibitory action of H2S on GluN1/2B receptors could limit the excessive activation in early age, the enhanced functionality of GluN1/2A receptor in the presence of this gasotransmitter can enlarge synaptic efficacy and promote synaptic plasticity in adults." @default.
• W2768244927 created "2017-12-04" @default.
• W2768244927 creator A5022152990 @default.
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• W2768244927 date "2017-11-24" @default.
• W2768244927 modified "2023-10-01" @default.
• W2768244927 title "Age-Dependent, Subunit Specific Action of Hydrogen Sulfide on GluN1/2A and GluN1/2B NMDA Receptors" @default.
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• W2768244927 cites W1918304474 @default.
• W2768244927 cites W1965321324 @default.
• W2768244927 cites W1966556202 @default.
• W2768244927 cites W1974569267 @default.
• W2768244927 cites W1976306764 @default.
• W2768244927 cites W1977390472 @default.
• W2768244927 cites W1980970275 @default.
• W2768244927 cites W1982895791 @default.
• W2768244927 cites W1987322407 @default.
• W2768244927 cites W1990216374 @default.
• W2768244927 cites W1990653561 @default.
• W2768244927 cites W1992549311 @default.
• W2768244927 cites W1994419985 @default.
• W2768244927 cites W1999088334 @default.
• W2768244927 cites W1999511826 @default.
• W2768244927 cites W2004897596 @default.
• W2768244927 cites W2006189794 @default.
• W2768244927 cites W2007166406 @default.
• W2768244927 cites W2011481428 @default.
• W2768244927 cites W2011629228 @default.
• W2768244927 cites W2012499074 @default.
• W2768244927 cites W2018566513 @default.
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• W2768244927 cites W2022873534 @default.
• W2768244927 cites W2026304612 @default.
• W2768244927 cites W2026540579 @default.
• W2768244927 cites W2033323717 @default.
• W2768244927 cites W2036089634 @default.
• W2768244927 cites W2039209034 @default.
• W2768244927 cites W2040806880 @default.
• W2768244927 cites W2046159731 @default.
• W2768244927 cites W2048397378 @default.
• W2768244927 cites W2063207603 @default.
• W2768244927 cites W2067469839 @default.
• W2768244927 cites W2067624239 @default.
• W2768244927 cites W2067757114 @default.
• W2768244927 cites W2070478570 @default.
• W2768244927 cites W2071580220 @default.
• W2768244927 cites W2073876100 @default.
• W2768244927 cites W2076357839 @default.
• W2768244927 cites W2077608361 @default.
• W2768244927 cites W2078366491 @default.
• W2768244927 cites W2078739145 @default.
• W2768244927 cites W2081413793 @default.
• W2768244927 cites W2085994848 @default.
• W2768244927 cites W2086543171 @default.
• W2768244927 cites W2091993675 @default.
• W2768244927 cites W2094327116 @default.
• W2768244927 cites W2110304317 @default.
• W2768244927 cites W2112309752 @default.
• W2768244927 cites W2128310583 @default.
• W2768244927 cites W2129015955 @default.
• W2768244927 cites W2134218486 @default.
• W2768244927 cites W2138397305 @default.
• W2768244927 cites W2141610173 @default.
• W2768244927 cites W2145547868 @default.
• W2768244927 cites W2165285173 @default.
• W2768244927 cites W2169346923 @default.
• W2768244927 cites W2205839428 @default.
• W2768244927 cites W2220129094 @default.
• W2768244927 cites W2279219668 @default.
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• W2768244927 cites W2601247425 @default.
• W2768244927 cites W2623984530 @default.
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• W2768244927 doi "https://doi.org/10.3389/fncel.2017.00375" @default.
• W2768244927 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5705612" @default.
• W2768244927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29225568" @default.
• W2768244927 hasPublicationYear "2017" @default.
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• W2768244927 hasAuthorship W2768244927A5022152990 @default.
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• W2768244927 hasAuthorship W2768244927A5082028281 @default.

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