FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768317957> ?p ?o ?g. }

• W2768317957 endingPage "11" @default.
• W2768317957 startingPage "1" @default.
• W2768317957 abstract "Pseudomonas aeruginosa is a problematic human pathogen resistant to almost all available antibiotics. The important prerequisite for these drugs to target this bacterium is an efficient delivery system. Siderophore-mediated drug delivery system is a promising approach to carry out antibiotics to the cells. Pyochelin, a siderophore of P. aeruginosa, was successfully synthesized in a five-step procedure. PEGylated liposomal pyochelin–antibiotic (L-Pch-Ab) carrier was fabricated by thin-film hydration method. L-Pch-Ab had an average size of 90.31 ± 0.11 nm holding a negative zeta potential at −54.12 ± 0.03 mV (PDI <2). The MIC determined by broth dilution method against three clinical strains isolated from burn wounds showed that L-Pch-Ab significantly reduced (≤16 µg/ml) the MIC values than those of free antibiotics. In the time kill assay, L-Pch-Ab was bactericidal against all strains at most time intervals at 2 × and 4 × MIC up to 24 h. TEM observations revealed that L-Pch-Ab was actively taken up by P. aeruginosa and exhibited membrane deformation within 2 h. Developed L-Pch-Ab fused intimately with the outer membrane of MDRPa and exhibited effective antibacterial activity than free Ab. Furthermore, L-Pch-Ab kills MDRPa within infected HaCaT keratinocytes without any cytotoxic effects at 4× MIC concentrations after 72 h. Thus, the specific targeting of L-Pch-Ab with its higher efficacy to deliver drug by limiting the toxicity will be a novel approach to fight infections caused by P. aeruginosa." @default.
• W2768317957 created "2017-12-04" @default.
• W2768317957 creator A5012985577 @default.
• W2768317957 creator A5034120047 @default.
• W2768317957 creator A5075326220 @default.
• W2768317957 creator A5088262550 @default.
• W2768317957 date "2017-11-27" @default.
• W2768317957 modified "2023-10-17" @default.
• W2768317957 title "Novel pyochelin-based PEGylated liposomes for enhanced delivery of antibiotics against resistant clinical isolates of <i>Pseudomonas aeruginosa</i>" @default.
• W2768317957 cites W1556305745 @default.
• W2768317957 cites W1963885628 @default.
• W2768317957 cites W1972122276 @default.
• W2768317957 cites W1984693521 @default.
• W2768317957 cites W1985581069 @default.
• W2768317957 cites W1992432352 @default.
• W2768317957 cites W2000985245 @default.
• W2768317957 cites W2008237695 @default.
• W2768317957 cites W2015542817 @default.
• W2768317957 cites W2018683681 @default.
• W2768317957 cites W2025067031 @default.
• W2768317957 cites W2025240035 @default.
• W2768317957 cites W2031423988 @default.
• W2768317957 cites W2031428283 @default.
• W2768317957 cites W2033877425 @default.
• W2768317957 cites W2034624108 @default.
• W2768317957 cites W2044678473 @default.
• W2768317957 cites W2046770720 @default.
• W2768317957 cites W2047570111 @default.
• W2768317957 cites W2054310958 @default.
• W2768317957 cites W2058043600 @default.
• W2768317957 cites W2062987698 @default.
• W2768317957 cites W2067796149 @default.
• W2768317957 cites W2076226743 @default.
• W2768317957 cites W2076272075 @default.
• W2768317957 cites W2099143902 @default.
• W2768317957 cites W2102378763 @default.
• W2768317957 cites W2106046373 @default.
• W2768317957 cites W2116294361 @default.
• W2768317957 cites W2119703555 @default.
• W2768317957 cites W2135755879 @default.
• W2768317957 cites W2139212381 @default.
• W2768317957 cites W2147038478 @default.
• W2768317957 cites W2149377698 @default.
• W2768317957 cites W2156618766 @default.
• W2768317957 cites W2168343206 @default.
• W2768317957 cites W2171045259 @default.
• W2768317957 cites W2300671107 @default.
• W2768317957 cites W2334334446 @default.
• W2768317957 cites W2599784444 @default.
• W2768317957 cites W2952746520 @default.
• W2768317957 doi "https://doi.org/10.1080/21691401.2017.1408119" @default.
• W2768317957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29179607" @default.
• W2768317957 hasPublicationYear "2017" @default.
• W2768317957 type Work @default.
• W2768317957 sameAs 2768317957 @default.
• W2768317957 citedByCount "8" @default.
• W2768317957 countsByYear W27683179572018 @default.
• W2768317957 countsByYear W27683179572019 @default.
• W2768317957 countsByYear W27683179572020 @default.
• W2768317957 countsByYear W27683179572021 @default.
• W2768317957 countsByYear W27683179572022 @default.
• W2768317957 crossrefType "journal-article" @default.
• W2768317957 hasAuthorship W2768317957A5012985577 @default.
• W2768317957 hasAuthorship W2768317957A5034120047 @default.
• W2768317957 hasAuthorship W2768317957A5075326220 @default.
• W2768317957 hasAuthorship W2768317957A5088262550 @default.
• W2768317957 hasBestOaLocation W27683179571 @default.
• W2768317957 hasConcept C104317684 @default.
• W2768317957 hasConcept C108319773 @default.
• W2768317957 hasConcept C146587185 @default.
• W2768317957 hasConcept C185154212 @default.
• W2768317957 hasConcept C185592680 @default.
• W2768317957 hasConcept C2776460866 @default.
• W2768317957 hasConcept C2777637488 @default.
• W2768317957 hasConcept C2778512257 @default.
• W2768317957 hasConcept C2779922871 @default.
• W2768317957 hasConcept C501593827 @default.
• W2768317957 hasConcept C523546767 @default.
• W2768317957 hasConcept C54355233 @default.
• W2768317957 hasConcept C547475151 @default.
• W2768317957 hasConcept C55493867 @default.
• W2768317957 hasConcept C86803240 @default.
• W2768317957 hasConcept C89423630 @default.
• W2768317957 hasConceptScore W2768317957C104317684 @default.
• W2768317957 hasConceptScore W2768317957C108319773 @default.
• W2768317957 hasConceptScore W2768317957C146587185 @default.
• W2768317957 hasConceptScore W2768317957C185154212 @default.
• W2768317957 hasConceptScore W2768317957C185592680 @default.
• W2768317957 hasConceptScore W2768317957C2776460866 @default.
• W2768317957 hasConceptScore W2768317957C2777637488 @default.
• W2768317957 hasConceptScore W2768317957C2778512257 @default.
• W2768317957 hasConceptScore W2768317957C2779922871 @default.
• W2768317957 hasConceptScore W2768317957C501593827 @default.
• W2768317957 hasConceptScore W2768317957C523546767 @default.
• W2768317957 hasConceptScore W2768317957C54355233 @default.
• W2768317957 hasConceptScore W2768317957C547475151 @default.
• W2768317957 hasConceptScore W2768317957C55493867 @default.
• W2768317957 hasConceptScore W2768317957C86803240 @default.

• next