Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768342014> ?p ?o ?g. }
- W2768342014 endingPage "3496" @default.
- W2768342014 startingPage "3486" @default.
- W2768342014 abstract "Growing evidence that cell-based therapies can improve recovery outcome in spinal cord injury (SCI) models substantiates their application for treatment of human with SCI. To address the effectiveness of these stem cells, potential candidates should be evaluated in proper SCI platform that allows direct real-time monitoring. In this study, the role of epidermal neural crest stem cells (EPI-NCSCs) was elucidated in an ex vivo model of SCI, and valproic acid (VPA) was administered to ameliorate the inhospitable context of injury for grafted EPI-NCSCs. Here the contusion was induced in organotypic spinal cord slice culture at day seven in vitro using a weight drop device and one hour post injury the GFP- expressing EPI-NCSCs were grafted followed by VPA administration. The evaluation of treated slices seven days after injury revealed that grafted stem cells survived on the injured slices and expressed GFAP, whereas they did not express any detectable levels of the neural progenitor marker doublecortin (DCX), which was expressed prior to transplantation. Immunoblotting data demonstrated that the expression of GFAP, BDNF, neurotrophin-3 (NT3), and Bcl2 increased significantly in stem cell treated slices. This study illustrated that the fate of transplanted stem cells has been directed to the glial lineage in the ex vivo context of injury and EPI-NCSCs may ameliorate the SCI condition through releasing neurotrophic factors directly and/or via inducing resident spinal cord cells." @default.
- W2768342014 created "2017-12-04" @default.
- W2768342014 creator A5001457493 @default.
- W2768342014 creator A5008212337 @default.
- W2768342014 creator A5027099936 @default.
- W2768342014 creator A5043861712 @default.
- W2768342014 creator A5057202965 @default.
- W2768342014 creator A5065473375 @default.
- W2768342014 date "2018-01-11" @default.
- W2768342014 modified "2023-10-03" @default.
- W2768342014 title "Epidermal neural crest stem cell‐derived glia enhance neurotrophic elements in an ex vivo model of spinal cord injury" @default.
- W2768342014 cites W1519487278 @default.
- W2768342014 cites W1524705340 @default.
- W2768342014 cites W1539226899 @default.
- W2768342014 cites W1899468091 @default.
- W2768342014 cites W1916806631 @default.
- W2768342014 cites W1957468634 @default.
- W2768342014 cites W1964951942 @default.
- W2768342014 cites W1966798058 @default.
- W2768342014 cites W1975681168 @default.
- W2768342014 cites W1979427131 @default.
- W2768342014 cites W1980379444 @default.
- W2768342014 cites W1983050224 @default.
- W2768342014 cites W1987349092 @default.
- W2768342014 cites W1987467507 @default.
- W2768342014 cites W1988875977 @default.
- W2768342014 cites W1992811273 @default.
- W2768342014 cites W1993908879 @default.
- W2768342014 cites W2000426718 @default.
- W2768342014 cites W2002623661 @default.
- W2768342014 cites W2011933865 @default.
- W2768342014 cites W2026674733 @default.
- W2768342014 cites W2031716025 @default.
- W2768342014 cites W2032413495 @default.
- W2768342014 cites W2034500742 @default.
- W2768342014 cites W2035311358 @default.
- W2768342014 cites W2042341137 @default.
- W2768342014 cites W2043434030 @default.
- W2768342014 cites W2052028842 @default.
- W2768342014 cites W2052275222 @default.
- W2768342014 cites W2052380760 @default.
- W2768342014 cites W2057879542 @default.
- W2768342014 cites W2058413487 @default.
- W2768342014 cites W2067760245 @default.
- W2768342014 cites W2070927514 @default.
- W2768342014 cites W2073130433 @default.
- W2768342014 cites W2074706210 @default.
- W2768342014 cites W2078145840 @default.
- W2768342014 cites W2079054696 @default.
- W2768342014 cites W2082182608 @default.
- W2768342014 cites W2083124467 @default.
- W2768342014 cites W2084092377 @default.
- W2768342014 cites W2098761559 @default.
- W2768342014 cites W2101667799 @default.
- W2768342014 cites W2102366389 @default.
- W2768342014 cites W2104284972 @default.
- W2768342014 cites W2125900572 @default.
- W2768342014 cites W2126168919 @default.
- W2768342014 cites W2127447774 @default.
- W2768342014 cites W2141957935 @default.
- W2768342014 cites W2151105260 @default.
- W2768342014 cites W2162167535 @default.
- W2768342014 cites W2164800591 @default.
- W2768342014 cites W2335534790 @default.
- W2768342014 cites W2345650033 @default.
- W2768342014 cites W2414791446 @default.
- W2768342014 cites W2514263768 @default.
- W2768342014 cites W4213096412 @default.
- W2768342014 doi "https://doi.org/10.1002/jcb.26520" @default.
- W2768342014 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29143997" @default.
- W2768342014 hasPublicationYear "2018" @default.
- W2768342014 type Work @default.
- W2768342014 sameAs 2768342014 @default.
- W2768342014 citedByCount "27" @default.
- W2768342014 countsByYear W27683420142018 @default.
- W2768342014 countsByYear W27683420142019 @default.
- W2768342014 countsByYear W27683420142020 @default.
- W2768342014 countsByYear W27683420142021 @default.
- W2768342014 countsByYear W27683420142022 @default.
- W2768342014 countsByYear W27683420142023 @default.
- W2768342014 crossrefType "journal-article" @default.
- W2768342014 hasAuthorship W2768342014A5001457493 @default.
- W2768342014 hasAuthorship W2768342014A5008212337 @default.
- W2768342014 hasAuthorship W2768342014A5027099936 @default.
- W2768342014 hasAuthorship W2768342014A5043861712 @default.
- W2768342014 hasAuthorship W2768342014A5057202965 @default.
- W2768342014 hasAuthorship W2768342014A5065473375 @default.
- W2768342014 hasConcept C104317684 @default.
- W2768342014 hasConcept C126322002 @default.
- W2768342014 hasConcept C136834591 @default.
- W2768342014 hasConcept C148738053 @default.
- W2768342014 hasConcept C150903083 @default.
- W2768342014 hasConcept C151730666 @default.
- W2768342014 hasConcept C160539049 @default.
- W2768342014 hasConcept C162746124 @default.
- W2768342014 hasConcept C169760540 @default.
- W2768342014 hasConcept C170493617 @default.
- W2768342014 hasConcept C201750760 @default.