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• W2768364830 abstract "Smoking is known to exacerbate HIV-1 pathogenesis, especially in monocytes, through the oxidative stress pathway. Exosomes are known to alter HIV-1 pathogenesis through inter-cellular communication. However, the role of exosomes in smoking-mediated HIV-1 pathogenesis is unknown. In this study, we investigated the effect of cigarette smoke condensate (CSC) on the characteristics of monocyte-derived exosomes and their influence on HIV-1 replication. Initially, we demonstrated that CSC reduced total protein and antioxidant capacity in exosomes derived from HIV-1-infected and uninfected macrophages. The exosomes from CSC-treated uninfected cells showed a protective effect against cytotoxicity and viral replication in HIV-1-infected macrophages. However, exosomes derived from HIV-1-infected cells lost their protective capacity. The results suggest that the exosomal defense is likely to be more effective during the early phase of HIV-1 infection and diminishes at the latter phase. Furthermore, we showed CSC-mediated upregulation of catalase in exosomes from uninfected cells, with a decrease in the levels of catalase and PRDX6 in exosomes derived from HIV-1-infected cells. These results suggest a potential role of antioxidant enzymes, which are differentially packaged into CSC-exposed HIV-1-infected and uninfected cell-derived exosomes, on HIV-1 replication of recipient cells. Overall, our study suggests a novel role of exosomes in tobacco-mediated HIV-1 pathogenesis." @default.
• W2768364830 created "2017-12-04" @default.
• W2768364830 creator A5016700147 @default.
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• W2768364830 creator A5047921626 @default.
• W2768364830 creator A5061920817 @default.
• W2768364830 creator A5068270554 @default.
• W2768364830 date "2017-11-23" @default.
• W2768364830 modified "2023-10-14" @default.
• W2768364830 title "Monocyte-derived exosomes upon exposure to cigarette smoke condensate alter their characteristics and show protective effect against cytotoxicity and HIV-1 replication" @default.
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• W2768364830 doi "https://doi.org/10.1038/s41598-017-16301-9" @default.
• W2768364830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5701054" @default.
• W2768364830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29170447" @default.
• W2768364830 hasPublicationYear "2017" @default.
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