FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768365173> ?p ?o ?g. }

• W2768365173 endingPage "60" @default.
• W2768365173 startingPage "51" @default.
• W2768365173 abstract "Our previous study has reported that the proactive secretion and role of central high mobility group box 1 (HMGB1) in lipopolysaccharide-induced depressive behavior. Here, the potential mechanism of HMGB1 mediating chronic-stress-induced depression through the kynurenine pathway (KP) was further explored both in vivo and in vitro. Depression model was established with the 4-week chronic unpredictable mild stress (CUMS). Sucrose preference and Barnes maze test were performed to reflect depressive behaviors. The ratio of kynurenine (KYN)/tryptophan (Trp) represented the enzyme activity of indoleamine-2,3-dioxygenase (IDO). Gene transcription and protein expression were assayed by real-time RT-PCR and western-blot or ELISA kit respectively. Along with depressive behaviors, HMGB1 concentrations in the hippocampus and serum substantially increased post 4-week CUMS exposure. Concurrent with the upregulated HMGB1 protein, the regulator of translocation of HMGB1, sirtuin 1 (SIRT1) concentration in the hippocampus remarkably increased. In addition to HMGB1 and SIRT1, IDO, the rate limiting enzyme of KP, was upregulated at the level of mRNA expression and enzyme activity in stressed hippocampi and LPS/HMGB1-treated hippocampal slices. The gene transcription of kynurenine monooxygenase (KMO) and kynureninase (KYNU) in the downstream of KP also increased both in vivo and in vitro. Mice treated with ethyl pyruvate (EP), the inhibitor of HMGB1 releasing, were observed with lower tendency of developing depressive behaviors and reduced activation of enzymes in KP. All of these experiments demonstrate that the role of HMGB1 on the induction of depressive behavior is mediated by KP activation." @default.
• W2768365173 created "2017-12-04" @default.
• W2768365173 creator A5004772470 @default.
• W2768365173 creator A5011825695 @default.
• W2768365173 creator A5022255776 @default.
• W2768365173 creator A5029088944 @default.
• W2768365173 creator A5044535935 @default.
• W2768365173 creator A5056168495 @default.
• W2768365173 creator A5057035600 @default.
• W2768365173 creator A5060100173 @default.
• W2768365173 creator A5078761985 @default.
• W2768365173 creator A5088926048 @default.
• W2768365173 date "2018-08-01" @default.
• W2768365173 modified "2023-10-18" @default.
• W2768365173 title "HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway" @default.
• W2768365173 cites W114145985 @default.
• W2768365173 cites W130054925 @default.
• W2768365173 cites W1541216541 @default.
• W2768365173 cites W1547937746 @default.
• W2768365173 cites W1607784912 @default.
• W2768365173 cites W1614084801 @default.
• W2768365173 cites W1861219352 @default.
• W2768365173 cites W1933859690 @default.
• W2768365173 cites W1947214230 @default.
• W2768365173 cites W1964904079 @default.
• W2768365173 cites W1983379130 @default.
• W2768365173 cites W1985982692 @default.
• W2768365173 cites W1987556983 @default.
• W2768365173 cites W1990201789 @default.
• W2768365173 cites W1994459847 @default.
• W2768365173 cites W1996454121 @default.
• W2768365173 cites W1996826305 @default.
• W2768365173 cites W1999516659 @default.
• W2768365173 cites W2001090873 @default.
• W2768365173 cites W2002642158 @default.
• W2768365173 cites W2003263043 @default.
• W2768365173 cites W2004266769 @default.
• W2768365173 cites W2005270780 @default.
• W2768365173 cites W2008239392 @default.
• W2768365173 cites W200859592 @default.
• W2768365173 cites W2008893382 @default.
• W2768365173 cites W2013236786 @default.
• W2768365173 cites W2013570295 @default.
• W2768365173 cites W2014566626 @default.
• W2768365173 cites W2026744070 @default.
• W2768365173 cites W2032142624 @default.
• W2768365173 cites W2047739268 @default.
• W2768365173 cites W2052371326 @default.
• W2768365173 cites W2055909204 @default.
• W2768365173 cites W2060050678 @default.
• W2768365173 cites W2073133225 @default.
• W2768365173 cites W2083347724 @default.
• W2768365173 cites W2086208662 @default.
• W2768365173 cites W2086410696 @default.
• W2768365173 cites W2087401845 @default.
• W2768365173 cites W2087714907 @default.
• W2768365173 cites W2087987871 @default.
• W2768365173 cites W2097391811 @default.
• W2768365173 cites W2102475367 @default.
• W2768365173 cites W2104414795 @default.
• W2768365173 cites W2115362578 @default.
• W2768365173 cites W2120276500 @default.
• W2768365173 cites W2131932927 @default.
• W2768365173 cites W2132324173 @default.
• W2768365173 cites W2135359579 @default.
• W2768365173 cites W2137877753 @default.
• W2768365173 cites W2139680138 @default.
• W2768365173 cites W2141438911 @default.
• W2768365173 cites W2141638391 @default.
• W2768365173 cites W2145910522 @default.
• W2768365173 cites W2146026881 @default.
• W2768365173 cites W2146381461 @default.
• W2768365173 cites W2150318471 @default.
• W2768365173 cites W2152958471 @default.
• W2768365173 cites W2172042148 @default.
• W2768365173 cites W2201607793 @default.
• W2768365173 cites W2239259805 @default.
• W2768365173 cites W2285911646 @default.
• W2768365173 cites W2345920049 @default.
• W2768365173 cites W2416929026 @default.
• W2768365173 cites W2464749518 @default.
• W2768365173 cites W2520908617 @default.
• W2768365173 cites W2527824850 @default.
• W2768365173 cites W2531113275 @default.
• W2768365173 cites W25841988 @default.
• W2768365173 cites W2590119696 @default.
• W2768365173 cites W577815675 @default.
• W2768365173 doi "https://doi.org/10.1016/j.bbi.2017.11.017" @default.
• W2768365173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29195782" @default.
• W2768365173 hasPublicationYear "2018" @default.
• W2768365173 type Work @default.
• W2768365173 sameAs 2768365173 @default.
• W2768365173 citedByCount "68" @default.
• W2768365173 countsByYear W27683651732018 @default.
• W2768365173 countsByYear W27683651732019 @default.
• W2768365173 countsByYear W27683651732020 @default.
• W2768365173 countsByYear W27683651732021 @default.
• W2768365173 countsByYear W27683651732022 @default.

• next