FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768438959> ?p ?o ?g. }

• W2768438959 endingPage "329" @default.
• W2768438959 startingPage "321" @default.
• W2768438959 abstract "Interaction between obesity and genetic factors involved in the regulatory pathways of glucose homeostasis may play a significant role in diabetes development in the obese. The aim of this study was to investigate the associations between the TCF7L2 rs7903146 polymorphism, adiponectin levels, age at onset of obesity and the occurrence of type 2 diabetes (T2D) in a sample of obese Polish adults.A total of 474 unrelated obese subjects were included in this study. Real-time PCR was used to detect the TCF7L2 rs7903146 polymorphism. Serum level of adiponectin was determined by the ELISA method. Standard assays were used to measure total cholesterol, HDL cholesterol, triglycerides, glucose and HbA1c concentrations. We used multiple logistic regression to identify factors associated with type 2 diabetes.We found that the T allele of rs7903146 was significantly associated with T2D risk (odds ratio of 1.59 for T allele, p = 0.005). This association persisted after adjusting for confounders in the recessive model (odds ratio of 3.54 for TT genotype, p = 0.011). Serum adiponectin levels were significantly lower in diabetic subjects than in nondiabetic individuals (3.6 vs. 5.6 µg/ml, p < 0.001). Participants who were obese at age ≥ 20 years had significantly higher odds of having T2D (OR = 4.94) than those with the onset of obesity before 20 years (p < 0.001).Our study highlights the significance of the relationship between the TCF7L2 polymorphism, a person's age at onset of obesity and the prevalence of T2D, and confirms lower adiponectin levels in obese diabetics in comparison to obese nondiabetics." @default.
• W2768438959 created "2017-12-04" @default.
• W2768438959 creator A5000099946 @default.
• W2768438959 creator A5023855409 @default.
• W2768438959 creator A5053760667 @default.
• W2768438959 creator A5054250522 @default.
• W2768438959 creator A5080440130 @default.
• W2768438959 date "2019-01-01" @default.
• W2768438959 modified "2023-10-17" @default.
• W2768438959 title "Age at onset of obesity, transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism, adiponectin levels and the risk of type 2 diabetes in obese patients" @default.
• W2768438959 cites W109874859 @default.
• W2768438959 cites W1918244402 @default.
• W2768438959 cites W1966650637 @default.
• W2768438959 cites W1969696027 @default.
• W2768438959 cites W1974545118 @default.
• W2768438959 cites W1975382160 @default.
• W2768438959 cites W1978590803 @default.
• W2768438959 cites W1981261500 @default.
• W2768438959 cites W1982380538 @default.
• W2768438959 cites W1988540453 @default.
• W2768438959 cites W1992214056 @default.
• W2768438959 cites W2017602185 @default.
• W2768438959 cites W2028458054 @default.
• W2768438959 cites W2032422942 @default.
• W2768438959 cites W2037406895 @default.
• W2768438959 cites W2042706232 @default.
• W2768438959 cites W2056393440 @default.
• W2768438959 cites W2079546795 @default.
• W2768438959 cites W2087008389 @default.
• W2768438959 cites W2094672900 @default.
• W2768438959 cites W2105912552 @default.
• W2768438959 cites W2107222217 @default.
• W2768438959 cites W2108931588 @default.
• W2768438959 cites W2114091184 @default.
• W2768438959 cites W2116404316 @default.
• W2768438959 cites W2124147826 @default.
• W2768438959 cites W2126718294 @default.
• W2768438959 cites W2141642891 @default.
• W2768438959 cites W2142831736 @default.
• W2768438959 cites W2152730582 @default.
• W2768438959 cites W2160009480 @default.
• W2768438959 cites W2162745491 @default.
• W2768438959 cites W2170769700 @default.
• W2768438959 cites W2304535577 @default.
• W2768438959 cites W2406659223 @default.
• W2768438959 cites W2461236753 @default.
• W2768438959 cites W2516942758 @default.
• W2768438959 cites W2596624061 @default.
• W2768438959 cites W4230870013 @default.
• W2768438959 cites W4302435679 @default.
• W2768438959 doi "https://doi.org/10.5114/aoms.2017.69638" @default.
• W2768438959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6425208" @default.
• W2768438959 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30899283" @default.
• W2768438959 hasPublicationYear "2019" @default.
• W2768438959 type Work @default.
• W2768438959 sameAs 2768438959 @default.
• W2768438959 citedByCount "17" @default.
• W2768438959 countsByYear W27684389592018 @default.
• W2768438959 countsByYear W27684389592019 @default.
• W2768438959 countsByYear W27684389592020 @default.
• W2768438959 countsByYear W27684389592021 @default.
• W2768438959 countsByYear W27684389592022 @default.
• W2768438959 countsByYear W27684389592023 @default.
• W2768438959 crossrefType "journal-article" @default.
• W2768438959 hasAuthorship W2768438959A5000099946 @default.
• W2768438959 hasAuthorship W2768438959A5023855409 @default.
• W2768438959 hasAuthorship W2768438959A5053760667 @default.
• W2768438959 hasAuthorship W2768438959A5054250522 @default.
• W2768438959 hasAuthorship W2768438959A5080440130 @default.
• W2768438959 hasBestOaLocation W27684389591 @default.
• W2768438959 hasConcept C104317684 @default.
• W2768438959 hasConcept C126322002 @default.
• W2768438959 hasConcept C134018914 @default.
• W2768438959 hasConcept C135763542 @default.
• W2768438959 hasConcept C153209595 @default.
• W2768438959 hasConcept C156957248 @default.
• W2768438959 hasConcept C2776782570 @default.
• W2768438959 hasConcept C2777180221 @default.
• W2768438959 hasConcept C2777391703 @default.
• W2768438959 hasConcept C39263347 @default.
• W2768438959 hasConcept C511355011 @default.
• W2768438959 hasConcept C54355233 @default.
• W2768438959 hasConcept C555293320 @default.
• W2768438959 hasConcept C71924100 @default.
• W2768438959 hasConcept C77350462 @default.
• W2768438959 hasConcept C86803240 @default.
• W2768438959 hasConceptScore W2768438959C104317684 @default.
• W2768438959 hasConceptScore W2768438959C126322002 @default.
• W2768438959 hasConceptScore W2768438959C134018914 @default.
• W2768438959 hasConceptScore W2768438959C135763542 @default.
• W2768438959 hasConceptScore W2768438959C153209595 @default.
• W2768438959 hasConceptScore W2768438959C156957248 @default.
• W2768438959 hasConceptScore W2768438959C2776782570 @default.
• W2768438959 hasConceptScore W2768438959C2777180221 @default.
• W2768438959 hasConceptScore W2768438959C2777391703 @default.
• W2768438959 hasConceptScore W2768438959C39263347 @default.
• W2768438959 hasConceptScore W2768438959C511355011 @default.
• W2768438959 hasConceptScore W2768438959C54355233 @default.

• next