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- W2768444316 abstract "The gene ybhA of Escherichia coli encodes a phosphatase that has an in vitro specificity to dephosphorylate pyridoxal 5ʹ-phosphate (PLP or vitamin B6), a co-factor for aminotransferases and other enzymes. In this study, we found that excess pyridoxal (PL) in a minimal medium resulted in excess PLP in vivo and growth inhibition, which was alleviated by YbhA overproduction. Conversely, the YbhA overproduction resulted in PLP shortage in vivo and the correlated reduction in growth rate, which was significantly negated by PL in the medium. In addition, the overproduction of a PL kinase, PdxK or PdxY, was inhibitory to cell growth only in the absence of the functional ybhA gene, and the growth defects were alleviated by casamino acids in the medium, which suggested that both the shortage of, and excess, PLP resulted in the disturbance of amino acid metabolism and cell growth, as revealed by a metabolome analysis." @default.
- W2768444316 created "2017-12-04" @default.
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- W2768444316 date "2017-01-01" @default.
- W2768444316 modified "2023-10-13" @default.
- W2768444316 title "Identification of YbhA as the pyridoxal 5ʹ-phosphate (PLP) phosphatase in <i>Escherichia coli</i>: Importance of PLP homeostasis on the bacterial growth" @default.
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- W2768444316 doi "https://doi.org/10.2323/jgam.2017.02.008" @default.
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