Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768499148> ?p ?o ?g. }
- W2768499148 abstract "Abstract We have investigated whether mineralocorticoid receptor activation can participate in the profibrotic effects of leptin in cardiac myofibroblasts, as well as the potential mechanisms involved. The presence of eplerenone reduced the leptin-induced increase in protein levels of collagen I, transforming growth factor β, connective tissue growth factor and galectin-3 and the levels of both total and mitochondrial of superoxide anion (O 2 . − ) in cardiac myofibroblasts. Likewise, the MEK/ERK inhibitor, PD98059, and the PI3/Akt inhibitor, LY294002, showed a similar pattern. Mitochondrial reactive oxygen species (ROS) scavenger (MitoTempo) attenuated the increase in body weight observed in rats fed a high fat diet (HFD). No differences were found in cardiac function or blood pressure among any group. However, the cardiac fibrosis and enhanced O 2 . -levels observed in HFD rats were attenuated by MitoTempo, which also prevented the increased circulating leptin and aldosterone levels in HFD fed animals. This study supports a role of mineralocorticoid receptor in the cardiac fibrosis induced by leptin in the context of obesity and highlights the role of the mitochondrial ROS in this process." @default.
- W2768499148 created "2017-12-04" @default.
- W2768499148 creator A5000531929 @default.
- W2768499148 creator A5010685420 @default.
- W2768499148 creator A5016226836 @default.
- W2768499148 creator A5027986729 @default.
- W2768499148 creator A5037595703 @default.
- W2768499148 creator A5048069237 @default.
- W2768499148 creator A5053601898 @default.
- W2768499148 creator A5060029047 @default.
- W2768499148 creator A5060479452 @default.
- W2768499148 creator A5062660706 @default.
- W2768499148 creator A5070393756 @default.
- W2768499148 creator A5078850591 @default.
- W2768499148 creator A5080744777 @default.
- W2768499148 creator A5089724634 @default.
- W2768499148 date "2017-12-01" @default.
- W2768499148 modified "2023-10-18" @default.
- W2768499148 title "The role of oxidative stress in the crosstalk between leptin and mineralocorticoid receptor in the cardiac fibrosis associated with obesity" @default.
- W2768499148 cites W1014880268 @default.
- W2768499148 cites W1906780894 @default.
- W2768499148 cites W1921235774 @default.
- W2768499148 cites W1981384991 @default.
- W2768499148 cites W1987050217 @default.
- W2768499148 cites W1989431420 @default.
- W2768499148 cites W1990001636 @default.
- W2768499148 cites W1996886067 @default.
- W2768499148 cites W1997611244 @default.
- W2768499148 cites W1999321766 @default.
- W2768499148 cites W2000257227 @default.
- W2768499148 cites W2005682229 @default.
- W2768499148 cites W2009442221 @default.
- W2768499148 cites W2023537963 @default.
- W2768499148 cites W2039078494 @default.
- W2768499148 cites W2044936627 @default.
- W2768499148 cites W2047942656 @default.
- W2768499148 cites W2059125810 @default.
- W2768499148 cites W2063376547 @default.
- W2768499148 cites W2063933725 @default.
- W2768499148 cites W2069026920 @default.
- W2768499148 cites W2083760388 @default.
- W2768499148 cites W2091169722 @default.
- W2768499148 cites W2094871379 @default.
- W2768499148 cites W2100041443 @default.
- W2768499148 cites W2102779499 @default.
- W2768499148 cites W2107805319 @default.
- W2768499148 cites W2108113751 @default.
- W2768499148 cites W2118860823 @default.
- W2768499148 cites W2122218625 @default.
- W2768499148 cites W2122341467 @default.
- W2768499148 cites W2124410786 @default.
- W2768499148 cites W2135932927 @default.
- W2768499148 cites W2141884086 @default.
- W2768499148 cites W2154081874 @default.
- W2768499148 cites W2154595232 @default.
- W2768499148 cites W2206025985 @default.
- W2768499148 cites W2244960457 @default.
- W2768499148 cites W2254521965 @default.
- W2768499148 cites W2293278356 @default.
- W2768499148 cites W2299099463 @default.
- W2768499148 cites W2547535704 @default.
- W2768499148 doi "https://doi.org/10.1038/s41598-017-17103-9" @default.
- W2768499148 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5711898" @default.
- W2768499148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29196758" @default.
- W2768499148 hasPublicationYear "2017" @default.
- W2768499148 type Work @default.
- W2768499148 sameAs 2768499148 @default.
- W2768499148 citedByCount "32" @default.
- W2768499148 countsByYear W27684991482018 @default.
- W2768499148 countsByYear W27684991482019 @default.
- W2768499148 countsByYear W27684991482020 @default.
- W2768499148 countsByYear W27684991482021 @default.
- W2768499148 countsByYear W27684991482022 @default.
- W2768499148 countsByYear W27684991482023 @default.
- W2768499148 crossrefType "journal-article" @default.
- W2768499148 hasAuthorship W2768499148A5000531929 @default.
- W2768499148 hasAuthorship W2768499148A5010685420 @default.
- W2768499148 hasAuthorship W2768499148A5016226836 @default.
- W2768499148 hasAuthorship W2768499148A5027986729 @default.
- W2768499148 hasAuthorship W2768499148A5037595703 @default.
- W2768499148 hasAuthorship W2768499148A5048069237 @default.
- W2768499148 hasAuthorship W2768499148A5053601898 @default.
- W2768499148 hasAuthorship W2768499148A5060029047 @default.
- W2768499148 hasAuthorship W2768499148A5060479452 @default.
- W2768499148 hasAuthorship W2768499148A5062660706 @default.
- W2768499148 hasAuthorship W2768499148A5070393756 @default.
- W2768499148 hasAuthorship W2768499148A5078850591 @default.
- W2768499148 hasAuthorship W2768499148A5080744777 @default.
- W2768499148 hasAuthorship W2768499148A5089724634 @default.
- W2768499148 hasBestOaLocation W27684991481 @default.
- W2768499148 hasConcept C126322002 @default.
- W2768499148 hasConcept C134018914 @default.
- W2768499148 hasConcept C14372207 @default.
- W2768499148 hasConcept C170493617 @default.
- W2768499148 hasConcept C185592680 @default.
- W2768499148 hasConcept C189135053 @default.
- W2768499148 hasConcept C2775960820 @default.
- W2768499148 hasConcept C2776151105 @default.
- W2768499148 hasConcept C2777420927 @default.
- W2768499148 hasConcept C2778175917 @default.