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- W2768509434 abstract "Leber's hereditary optic neuropathy (LHON) is a common inherited mitochondrial disorder that is characterized by the degeneration of the optic nerves, leading to vision loss. The major mutations in the mitochondrial genes ND1, ND4, and ND6 of LHON subjects are found to increase the oxidative stress experienced by the optic nerve cell, thereby leading to nerve cell damage. Accurate treatments are not available and drugs that are commercially available like Idebenone, EPI-743, and Bendavia with their antioxidant role help in reducing the oxidative stress experienced by the cell thereby preventing the progression of the disease. Genetic counseling plays an effective role in making the family members aware of the inheritance pattern of the disease. Gene therapy is an alternative for curing the disease but is still under study. This review focuses on the role of mitochondrial genes in causing LHON and therapeutics available for treating the disease. A systematic search has been adopted in various databases using the keywords “LHON,” “mitochondria,” “ND1,” “ND4,” “ND6,” and “therapy” and the following review on mitochondrial genetics and therapeutics of LHON has been developed with obtained articles from 1988 to 2017." @default.
- W2768509434 created "2017-12-04" @default.
- W2768509434 creator A5068037582 @default.
- W2768509434 creator A5088144839 @default.
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- W2768509434 date "2017-01-01" @default.
- W2768509434 modified "2023-10-15" @default.
- W2768509434 title "Mitochondrial genetics and therapeutic overview of Leber's hereditary optic neuropathy" @default.
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- W2768509434 doi "https://doi.org/10.4103/ijo.ijo_358_17" @default.
- W2768509434 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5700573" @default.
- W2768509434 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29133631" @default.
- W2768509434 hasPublicationYear "2017" @default.
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