Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768542634> ?p ?o ?g. }
- W2768542634 endingPage "2519" @default.
- W2768542634 startingPage "2519" @default.
- W2768542634 abstract "G protein-coupled receptors (GPCRs) are cell surface receptors that respond to a wide variety of stimuli, from light, odorants, hormones, and neurotransmitters to proteins and extracellular calcium. GPCRs represent the largest family of signaling proteins targeted by many clinically used drugs. Recent studies shed light on the conformational changes that accompany GPCR activation and the structural state of the receptor necessary for the interactions with the three classes of proteins that preferentially bind active GPCRs, G proteins, G protein-coupled receptor kinases (GRKs), and arrestins. Importantly, structural and biophysical studies also revealed activation-related conformational changes in these three types of signal transducers. Here, we summarize what is already known and point out questions that still need to be answered. Clear understanding of the structural basis of signaling by GPCRs and their interaction partners would pave the way to designing signaling-biased proteins with scientific and therapeutic potential." @default.
- W2768542634 created "2017-12-04" @default.
- W2768542634 creator A5049089914 @default.
- W2768542634 creator A5055148764 @default.
- W2768542634 date "2017-11-24" @default.
- W2768542634 modified "2023-09-30" @default.
- W2768542634 title "Molecular Mechanisms of GPCR Signaling: A Structural Perspective" @default.
- W2768542634 cites W1482828226 @default.
- W2768542634 cites W1489775551 @default.
- W2768542634 cites W1498831674 @default.
- W2768542634 cites W1562093773 @default.
- W2768542634 cites W1603105681 @default.
- W2768542634 cites W1607777232 @default.
- W2768542634 cites W1659650576 @default.
- W2768542634 cites W1825353903 @default.
- W2768542634 cites W1955508706 @default.
- W2768542634 cites W1969801856 @default.
- W2768542634 cites W1971126800 @default.
- W2768542634 cites W1974710770 @default.
- W2768542634 cites W1977484356 @default.
- W2768542634 cites W1978997108 @default.
- W2768542634 cites W1979103781 @default.
- W2768542634 cites W1979233943 @default.
- W2768542634 cites W1980058356 @default.
- W2768542634 cites W1981561980 @default.
- W2768542634 cites W1989563075 @default.
- W2768542634 cites W1989924590 @default.
- W2768542634 cites W1989969172 @default.
- W2768542634 cites W1989971979 @default.
- W2768542634 cites W1990240164 @default.
- W2768542634 cites W1994539207 @default.
- W2768542634 cites W1998158537 @default.
- W2768542634 cites W2006268283 @default.
- W2768542634 cites W2006803138 @default.
- W2768542634 cites W2012571494 @default.
- W2768542634 cites W2015176049 @default.
- W2768542634 cites W2015590113 @default.
- W2768542634 cites W2017218397 @default.
- W2768542634 cites W2017875329 @default.
- W2768542634 cites W2018506708 @default.
- W2768542634 cites W2019742616 @default.
- W2768542634 cites W2020601776 @default.
- W2768542634 cites W2024850327 @default.
- W2768542634 cites W2025605951 @default.
- W2768542634 cites W2026493203 @default.
- W2768542634 cites W2030222651 @default.
- W2768542634 cites W2034782869 @default.
- W2768542634 cites W2037714888 @default.
- W2768542634 cites W2040130844 @default.
- W2768542634 cites W2043111450 @default.
- W2768542634 cites W2043116643 @default.
- W2768542634 cites W2048669565 @default.
- W2768542634 cites W2053071903 @default.
- W2768542634 cites W2054663006 @default.
- W2768542634 cites W2059551149 @default.
- W2768542634 cites W2061109953 @default.
- W2768542634 cites W2061244275 @default.
- W2768542634 cites W2064664612 @default.
- W2768542634 cites W2064861213 @default.
- W2768542634 cites W2065960915 @default.
- W2768542634 cites W2067482553 @default.
- W2768542634 cites W2068003883 @default.
- W2768542634 cites W2077936290 @default.
- W2768542634 cites W2078026261 @default.
- W2768542634 cites W2078108096 @default.
- W2768542634 cites W2078128727 @default.
- W2768542634 cites W2079520721 @default.
- W2768542634 cites W2086181965 @default.
- W2768542634 cites W2087663632 @default.
- W2768542634 cites W2090858556 @default.
- W2768542634 cites W2092532048 @default.
- W2768542634 cites W2096803511 @default.
- W2768542634 cites W2102459914 @default.
- W2768542634 cites W2109014958 @default.
- W2768542634 cites W2113862155 @default.
- W2768542634 cites W2114487805 @default.
- W2768542634 cites W2130632774 @default.
- W2768542634 cites W2141410829 @default.
- W2768542634 cites W2143071207 @default.
- W2768542634 cites W2147874971 @default.
- W2768542634 cites W2150530449 @default.
- W2768542634 cites W2157724269 @default.
- W2768542634 cites W2164424131 @default.
- W2768542634 cites W2165726219 @default.
- W2768542634 cites W2165775221 @default.
- W2768542634 cites W2168966210 @default.
- W2768542634 cites W2169279934 @default.
- W2768542634 cites W2169290598 @default.
- W2768542634 cites W2295526222 @default.
- W2768542634 cites W2312328575 @default.
- W2768542634 cites W2340675996 @default.
- W2768542634 cites W2341595256 @default.
- W2768542634 cites W2470669072 @default.
- W2768542634 cites W2474393700 @default.
- W2768542634 cites W2475511529 @default.
- W2768542634 cites W2499343687 @default.
- W2768542634 cites W2519198844 @default.
- W2768542634 cites W2532143627 @default.