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• W2768657784 endingPage "398" @default.
• W2768657784 startingPage "386" @default.
• W2768657784 abstract "We have earlier demonstrated that a Status Epilepticus (SE) during CNS development has long-lasting effects on cholinergic neurotransmission, detectable in vitro and in vivo. In this work, we aimed to localize changes in temporal (T) vs septal (S) hippocampus and to correlate adult CA3 interictal epileptiform discharge (IED) frequency changes to those of Ripples (R) and Fast Ripples (FR) of the High-Frequency Oscillations (HFOs). Spontaneous IEDs were induced by bathing slices in Mg2+-free ACSF or in 4-Aminopyridine (4-AP, 50 µM) and data were analyzed separately for each model. IED frequencies were similar in same origin normal (N) slices across models, but differed in SE slices, being lower in Mg2+-free ACSF than in 4-AP, suggesting a post-SE long-term increase in a K+ conductance. Rs and FRs detected within IEDs had generally higher power in 4-AP than in Mg2+-free ACSF; FR/R ratio was the highest in T-SE slices in 4-AP and similar in all other slice groups. Carbachol or eserine increased IED rates universally, but had region- and conditioning-specific effects on HFOs, suggesting that IED frequency and HFOs represent possibly independent indices of excitability. The muscarinic antagonist atropine depressed IED rates with increasing effectiveness in S slices post-SE in both models. In conclusion, the long-term effects of an immature SE are region-specific within the hippocampus, affect differently synchronizing components like the IED frequency and HFOs and may shape neurotransmitter effects (ACh) on neuronal networks, thus affecting seizure threshold and information processing, especially in behavioral conditions of rising extracellular ACh levels." @default.
• W2768657784 created "2017-12-04" @default.
• W2768657784 creator A5046832631 @default.
• W2768657784 creator A5062896176 @default.
• W2768657784 creator A5087367713 @default.
• W2768657784 date "2018-01-01" @default.
• W2768657784 modified "2023-10-13" @default.
• W2768657784 title "Immature Status Epilepticus: In Vitro Models Reveal Differences in Cholinergic Control and HFO Properties of Adult CA3 Interictal Discharges in Temporal vs Septal Hippocampus" @default.
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• W2768657784 doi "https://doi.org/10.1016/j.neuroscience.2017.11.029" @default.
• W2768657784 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29175154" @default.
• W2768657784 hasPublicationYear "2018" @default.
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