Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768705468> ?p ?o ?g. }
- W2768705468 abstract "At the kilo- to megabase pair scales, eukaryotic genomes are partitioned into self-interacting modules or topologically associated domains (TADs) that associate to form nuclear compartments. Here, we combine high-content super-resolution microscopies with state-of-the-art DNA-labeling methods to reveal the variability in the multiscale organization of the Drosophila genome. We find that association frequencies within TADs and between TAD borders are below ~10%, independently of TAD size, epigenetic state, or cell type. Critically, despite this large heterogeneity, we are able to visualize nanometer-sized epigenetic domains at the single-cell level. In addition, absolute contact frequencies within and between TADs are to a large extent defined by genomic distance, higher-order chromosome architecture, and epigenetic identity. We propose that TADs and compartments are organized by multiple, small-frequency, yet specific interactions that are regulated by epigenetics and transcriptional state." @default.
- W2768705468 created "2017-12-04" @default.
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- W2768705468 date "2017-11-24" @default.
- W2768705468 modified "2023-10-18" @default.
- W2768705468 title "Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions" @default.
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- W2768705468 doi "https://doi.org/10.1038/s41467-017-01962-x" @default.
- W2768705468 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5700980" @default.
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