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- W2768713055 endingPage "1094" @default.
- W2768713055 startingPage "1069" @default.
- W2768713055 abstract "Publisher Summary Growth hormone (GH) has distinct effects on the skeleton in terms of both linear growth and bone remodeling. Longitudinal growth results from the activity of GH on the skeleton, particularly at the cartilaginous growth plate. In human bone, proliferating chondrocytes express IGFIRs and are responsive to paracrine insulin-like growth factors (IGFs) secreted by differentiated cartilage cells. GH may also have its own effect on linear growth, independent of IGF-I. IGFs are critical in mediating the GH skeletal response. Remodeling is the sum of several distinct events beginning with activation of lining cells, followed by osteoclast recruitment, osteoblast differentiation, and osteocyte formation. In addition to regulating osteoblast function, several groups have shown that skeletal IGF-I can stimulate osteoclast recruitment and differentiation either directly through the IGF-IR or via RANKL expression. Finally, anti-resorptive agents have been considered as cornerstone therapeutics for osteoporosis. Anabolic agents can directly stimulate bone formation, which might have greater potential than the anti-resorptives to increase bone mass and to decrease fractures. Therefore, there is an emerging interest in developing anabolic agents including PTH, GH, and IGF-I to treat osteoporosis." @default.
- W2768713055 created "2017-12-04" @default.
- W2768713055 creator A5015017082 @default.
- W2768713055 creator A5047044979 @default.
- W2768713055 date "2008-01-01" @default.
- W2768713055 modified "2023-10-15" @default.
- W2768713055 title "Insulin-like Growth Factors and the IGF Binding Proteins" @default.
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