Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768713068> ?p ?o ?g. }
- W2768713068 abstract "Adipokines are secreted by adipose tissue and play an important role in the regulation of lipid metabolism. However, the information regarding adipokines in goats is limited. PPARγ is a key gene in adipocyte differentiation and activates adipokine genes. Rosiglitazone is a PPARγ agonist and can promote the expression of PPARγ to increase the expression of lipogenesis-related genes. Therefore, investigation of the relationship between rosiglitazone and adipokines will help us to better understand the function of PPARγ in lipid metabolism in Tibetan goats. In this study, we cloned the resistin (RETN), apelin (APLN), fibroblast growth factor 21 (FGF21), and visfatin (NAMPT) genes from non-pregnant female Tibetan goat adipose tissue. APLN and NAMPT were predominantly expressed in the kidney, and FGF21 was expressed at the highest levels in the liver in vivo. In fat tissues, the highest expression levels of FGF21 and RETN were detected in omental fat, whereas their expression in perirenal and subcutaneous fat was extremely weak. APLN and NAMPT were abundantly expressed in omental and subcutaneous fat in vivo. In addition, the four adipokines had different expression profiles during goat adipocyte differentiation in vitro. Oil red O staining showed that rosiglitazone could promote adipocyte differentiation and lipid droplet formation. In addition, rosiglitazone significantly increased the expression of FGF21 and RETN (p<0.05) but decreased the expression of APLN and NAMPT (p<0.05). These results suggest that the four adipocytokine genes may have different roles during goat adipocyte differentiation. And PPARγ could regulate the expression of the four adipokines, but the detailed regulatory mechanism still needs to be elucidated." @default.
- W2768713068 created "2017-12-04" @default.
- W2768713068 creator A5003642180 @default.
- W2768713068 creator A5027475930 @default.
- W2768713068 creator A5057310646 @default.
- W2768713068 creator A5064203710 @default.
- W2768713068 creator A5067545412 @default.
- W2768713068 creator A5087167893 @default.
- W2768713068 creator A5088888341 @default.
- W2768713068 date "2018-02-01" @default.
- W2768713068 modified "2023-10-17" @default.
- W2768713068 title "Identification and expression patterns of adipokine genes during adipocyte differentiation in the Tibetan goat ( Capra hircus )" @default.
- W2768713068 cites W1513674275 @default.
- W2768713068 cites W1578531215 @default.
- W2768713068 cites W1675830194 @default.
- W2768713068 cites W1965054829 @default.
- W2768713068 cites W1968091833 @default.
- W2768713068 cites W1971619616 @default.
- W2768713068 cites W1974159561 @default.
- W2768713068 cites W1978993973 @default.
- W2768713068 cites W1984699310 @default.
- W2768713068 cites W1989361659 @default.
- W2768713068 cites W1989584881 @default.
- W2768713068 cites W1994268431 @default.
- W2768713068 cites W1996713062 @default.
- W2768713068 cites W2000993281 @default.
- W2768713068 cites W2001727439 @default.
- W2768713068 cites W2002811789 @default.
- W2768713068 cites W2008589619 @default.
- W2768713068 cites W2012067669 @default.
- W2768713068 cites W2018946767 @default.
- W2768713068 cites W2019864042 @default.
- W2768713068 cites W2025912597 @default.
- W2768713068 cites W2027091986 @default.
- W2768713068 cites W2030051876 @default.
- W2768713068 cites W2032834779 @default.
- W2768713068 cites W2033204507 @default.
- W2768713068 cites W2037334856 @default.
- W2768713068 cites W2047726905 @default.
- W2768713068 cites W2058609149 @default.
- W2768713068 cites W2060968728 @default.
- W2768713068 cites W2067784377 @default.
- W2768713068 cites W2072916969 @default.
- W2768713068 cites W2075714512 @default.
- W2768713068 cites W2079132151 @default.
- W2768713068 cites W2079635857 @default.
- W2768713068 cites W2082444990 @default.
- W2768713068 cites W2082930819 @default.
- W2768713068 cites W2088799941 @default.
- W2768713068 cites W2094599609 @default.
- W2768713068 cites W2097544331 @default.
- W2768713068 cites W2100232436 @default.
- W2768713068 cites W2104437296 @default.
- W2768713068 cites W2110678596 @default.
- W2768713068 cites W2111653877 @default.
- W2768713068 cites W2122428157 @default.
- W2768713068 cites W2127841213 @default.
- W2768713068 cites W2129224037 @default.
- W2768713068 cites W2133706171 @default.
- W2768713068 cites W2134260528 @default.
- W2768713068 cites W2134328213 @default.
- W2768713068 cites W2134810803 @default.
- W2768713068 cites W2135041172 @default.
- W2768713068 cites W2135110328 @default.
- W2768713068 cites W2137888441 @default.
- W2768713068 cites W2147029239 @default.
- W2768713068 cites W2148720103 @default.
- W2768713068 cites W2152509794 @default.
- W2768713068 cites W2161324995 @default.
- W2768713068 cites W2167878797 @default.
- W2768713068 cites W2168050451 @default.
- W2768713068 cites W2171342857 @default.
- W2768713068 cites W2287604137 @default.
- W2768713068 cites W2474616143 @default.
- W2768713068 cites W2486625910 @default.
- W2768713068 cites W2504893897 @default.
- W2768713068 cites W2580690439 @default.
- W2768713068 cites W2605230677 @default.
- W2768713068 cites W2614112860 @default.
- W2768713068 cites W2728197278 @default.
- W2768713068 cites W2741630457 @default.
- W2768713068 cites W3139596979 @default.
- W2768713068 cites W61964868 @default.
- W2768713068 doi "https://doi.org/10.1016/j.gene.2017.11.069" @default.
- W2768713068 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29197590" @default.
- W2768713068 hasPublicationYear "2018" @default.
- W2768713068 type Work @default.
- W2768713068 sameAs 2768713068 @default.
- W2768713068 citedByCount "4" @default.
- W2768713068 countsByYear W27687130682019 @default.
- W2768713068 countsByYear W27687130682021 @default.
- W2768713068 crossrefType "journal-article" @default.
- W2768713068 hasAuthorship W2768713068A5003642180 @default.
- W2768713068 hasAuthorship W2768713068A5027475930 @default.
- W2768713068 hasAuthorship W2768713068A5057310646 @default.
- W2768713068 hasAuthorship W2768713068A5064203710 @default.
- W2768713068 hasAuthorship W2768713068A5067545412 @default.
- W2768713068 hasAuthorship W2768713068A5087167893 @default.
- W2768713068 hasAuthorship W2768713068A5088888341 @default.
- W2768713068 hasConcept C122927707 @default.