Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768734558> ?p ?o ?g. }
- W2768734558 abstract "Background Lead is a toxic metal that is widely distributed in the environment where caftaric acid (CA) is the ester form of caffeic acid where CA is the major dietary polyphenol present in various foods and beverages. The aim of this study was to evaluate the effect of CA in lead acetate (LA)-associated nephrotoxicity through antidiuretic, antioxidant and anti-apoptotic activities. Methods Forty-eight male albino rats divided into six equal groups; group 1 control injected intraperitoneally (ip) with saline (1 mL/kg of bw) over two weeks period, group 2 injected ip with CA (80 mg/kg of bw) over two weeks period, groups 3, 4, 5 and 6 injected ip with 100 μmol/kg of bw LA over two weeks period where groups 4, 5 & 6 co-injected ip with 1-deamino-8-D-arginine vasopressin (dDAVP) drug (1 mg/kg of bw), CA (40 mg/kg of bw), and CA (80 mg/kg of bw), respectively. Results The results obtained revealed that LA induced a significant decrease in kidney weight and serum sodium, potassium and chloride, but caused a significant increase in urinary volume, urinary excretion of sodium, potassium and chloride, serum urea, creatinine and uric acid. The LA also caused a significant decrease in kidney superoxide dismutase, glutathione peroxidase and induced a significant decrease in glutathione level while caused an increase in lipid peroxidation level. In addition, LA caused a decrease in p53 expression while induced an increase in bcl-2 expression in the kidney tissues. Co-injection of CA to LA-treated group restored all the above parameters to approach the normal values. The results supported with histopathological examinations. Conclusions In conclusion, the effect of CA on LA-related nephrotoxicity was occurred through antidiuretic, antioxidant, anti-apoptotic activities where the effect of CA was dose dependent." @default.
- W2768734558 created "2017-12-04" @default.
- W2768734558 creator A5022172833 @default.
- W2768734558 creator A5086191974 @default.
- W2768734558 date "2017-11-17" @default.
- W2768734558 modified "2023-09-26" @default.
- W2768734558 title "Role of caftaric acid in lead-associated nephrotoxicity in rats via antidiuretic, antioxidant and anti-apoptotic activities" @default.
- W2768734558 cites W1506685396 @default.
- W2768734558 cites W1780504177 @default.
- W2768734558 cites W178972529 @default.
- W2768734558 cites W1914889820 @default.
- W2768734558 cites W1966465630 @default.
- W2768734558 cites W1968246726 @default.
- W2768734558 cites W1971862114 @default.
- W2768734558 cites W1983310681 @default.
- W2768734558 cites W1986948719 @default.
- W2768734558 cites W1993637822 @default.
- W2768734558 cites W1995533037 @default.
- W2768734558 cites W1999717197 @default.
- W2768734558 cites W2004297939 @default.
- W2768734558 cites W2006370393 @default.
- W2768734558 cites W2006457793 @default.
- W2768734558 cites W2010700111 @default.
- W2768734558 cites W2011197560 @default.
- W2768734558 cites W2012290081 @default.
- W2768734558 cites W2013696953 @default.
- W2768734558 cites W2018438226 @default.
- W2768734558 cites W2019736488 @default.
- W2768734558 cites W2021512909 @default.
- W2768734558 cites W2031059593 @default.
- W2768734558 cites W2040136224 @default.
- W2768734558 cites W2041769533 @default.
- W2768734558 cites W2043402368 @default.
- W2768734558 cites W2050671409 @default.
- W2768734558 cites W2054301127 @default.
- W2768734558 cites W2055888757 @default.
- W2768734558 cites W2055973923 @default.
- W2768734558 cites W2057294994 @default.
- W2768734558 cites W2067557243 @default.
- W2768734558 cites W2069403248 @default.
- W2768734558 cites W2073212540 @default.
- W2768734558 cites W2081541525 @default.
- W2768734558 cites W2088464173 @default.
- W2768734558 cites W2090634027 @default.
- W2768734558 cites W2123382908 @default.
- W2768734558 cites W2131608677 @default.
- W2768734558 cites W2135749989 @default.
- W2768734558 cites W2139989045 @default.
- W2768734558 cites W2155093601 @default.
- W2768734558 cites W2181606994 @default.
- W2768734558 cites W2260490359 @default.
- W2768734558 cites W2273833263 @default.
- W2768734558 cites W2290466312 @default.
- W2768734558 cites W2290960977 @default.
- W2768734558 cites W2326307436 @default.
- W2768734558 cites W611120642 @default.
- W2768734558 doi "https://doi.org/10.1515/jcim-2017-0024" @default.
- W2768734558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29148979" @default.
- W2768734558 hasPublicationYear "2017" @default.
- W2768734558 type Work @default.
- W2768734558 sameAs 2768734558 @default.
- W2768734558 citedByCount "4" @default.
- W2768734558 countsByYear W27687345582018 @default.
- W2768734558 countsByYear W27687345582022 @default.
- W2768734558 crossrefType "journal-article" @default.
- W2768734558 hasAuthorship W2768734558A5022172833 @default.
- W2768734558 hasAuthorship W2768734558A5086191974 @default.
- W2768734558 hasConcept C10146269 @default.
- W2768734558 hasConcept C126189478 @default.
- W2768734558 hasConcept C126322002 @default.
- W2768734558 hasConcept C134018914 @default.
- W2768734558 hasConcept C178790620 @default.
- W2768734558 hasConcept C185592680 @default.
- W2768734558 hasConcept C2775838275 @default.
- W2768734558 hasConcept C2778004101 @default.
- W2768734558 hasConcept C2778760513 @default.
- W2768734558 hasConcept C2779881121 @default.
- W2768734558 hasConcept C2780091579 @default.
- W2768734558 hasConcept C2780306776 @default.
- W2768734558 hasConcept C2780343553 @default.
- W2768734558 hasConcept C2780829032 @default.
- W2768734558 hasConcept C537181965 @default.
- W2768734558 hasConcept C55493867 @default.
- W2768734558 hasConcept C71924100 @default.
- W2768734558 hasConcept C98274493 @default.
- W2768734558 hasConceptScore W2768734558C10146269 @default.
- W2768734558 hasConceptScore W2768734558C126189478 @default.
- W2768734558 hasConceptScore W2768734558C126322002 @default.
- W2768734558 hasConceptScore W2768734558C134018914 @default.
- W2768734558 hasConceptScore W2768734558C178790620 @default.
- W2768734558 hasConceptScore W2768734558C185592680 @default.
- W2768734558 hasConceptScore W2768734558C2775838275 @default.
- W2768734558 hasConceptScore W2768734558C2778004101 @default.
- W2768734558 hasConceptScore W2768734558C2778760513 @default.
- W2768734558 hasConceptScore W2768734558C2779881121 @default.
- W2768734558 hasConceptScore W2768734558C2780091579 @default.
- W2768734558 hasConceptScore W2768734558C2780306776 @default.
- W2768734558 hasConceptScore W2768734558C2780343553 @default.
- W2768734558 hasConceptScore W2768734558C2780829032 @default.
- W2768734558 hasConceptScore W2768734558C537181965 @default.