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- W2768758846 abstract "Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) are necessary for functional cell integrity. Preconditioning (PC), as we define it, is an acquired protection or resilience by a cell, tissue, or organ to a lethal stimulus enabled by a previous sublethal stressor or stimulus. In this study, we provide evidence that the omega-3 fatty acid docosahexaenoic acid (DHA) and its derivatives, the docosanoids 17-hydroxy docosahexaenoic acid (17-HDHA) and neuroprotectin D1 (NPD1), facilitate cell survival in both in vitro and in vivo models of retinal PC. We also demonstrate that PC requires the enzyme 15-lipoxygenase-1 (15-LOX-1), which synthesizes 17-HDHA and NPD1, and that this is specific to docosanoid signaling despite the concomitant release of the omega-6 arachidonic acid and eicosanoid synthesis. These findings advocate that DHA and docosanoids are protective enablers of PC in photoreceptor and retinal pigment epithelial cells." @default.
- W2768758846 created "2017-12-04" @default.
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- W2768758846 date "2017-11-24" @default.
- W2768758846 modified "2023-10-14" @default.
- W2768758846 title "Retinal Pigment Epithelium and Photoreceptor Preconditioning Protection Requires Docosanoid Signaling" @default.
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- W2768758846 doi "https://doi.org/10.1007/s10571-017-0565-2" @default.
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