Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768762471> ?p ?o ?g. }
- W2768762471 endingPage "386" @default.
- W2768762471 startingPage "373" @default.
- W2768762471 abstract "Although tRNAs participate in the essential function of protein translation in the cytoplasm, tRNA transcription and numerous processing steps occur in the nucleus. This subcellular separation between tRNA biogenesis and function requires that tRNAs be efficiently delivered to the cytoplasm in a step termed primary tRNA nuclear export. Surprisingly, tRNA nuclear-cytoplasmic traffic is not unidirectional, but, rather, movement is bidirectional. Cytoplasmic tRNAs are imported back to the nucleus by the tRNA retrograde nuclear import step which is conserved from budding yeast to vertebrate cells and has been hijacked by viruses, such as HIV, for nuclear import of the viral reverse transcription complex in human cells. Under appropriate environmental conditions cytoplasmic tRNAs that have been imported into the nucleus return to the cytoplasm via the 3rd nuclear-cytoplasmic shuttling step termed tRNA nuclear re-export, that again is conserved from budding yeast to vertebrate cells. We describe the 3 steps of tRNA nuclear-cytoplasmic movements and their regulation. There are multiple tRNA nuclear export and import pathways. The different tRNA nuclear exporters appear to possess substrate specificity leading to the tantalizing possibility that the cellular proteome may be regulated at the level of tRNA nuclear export. Moreover, in some organisms, such as budding yeast, the pre-tRNA splicing heterotetrameric endonuclease (SEN), which removes introns from pre-tRNAs, resides on the cytoplasmic surface of the mitochondria. Therefore, we also describe the localization of the SEN complex to mitochondria and splicing of pre-tRNA on mitochondria, which occurs prior to the participation of tRNAs in protein translation. This article is part of a Special Issue entitled: SI: Regulation of tRNA synthesis and modification in physiological conditions and disease edited by Dr. Boguta Magdalena." @default.
- W2768762471 created "2017-12-04" @default.
- W2768762471 creator A5012805211 @default.
- W2768762471 creator A5016580707 @default.
- W2768762471 creator A5039105211 @default.
- W2768762471 creator A5072653299 @default.
- W2768762471 date "2018-04-01" @default.
- W2768762471 modified "2023-10-12" @default.
- W2768762471 title "tRNA dynamics between the nucleus, cytoplasm and mitochondrial surface: Location, location, location" @default.
- W2768762471 cites W1487850295 @default.
- W2768762471 cites W1541876869 @default.
- W2768762471 cites W1572640010 @default.
- W2768762471 cites W1583965246 @default.
- W2768762471 cites W1766138704 @default.
- W2768762471 cites W1792619367 @default.
- W2768762471 cites W1810708914 @default.
- W2768762471 cites W1821016817 @default.
- W2768762471 cites W1906138272 @default.
- W2768762471 cites W1917364401 @default.
- W2768762471 cites W1926882714 @default.
- W2768762471 cites W1934704664 @default.
- W2768762471 cites W1935366897 @default.
- W2768762471 cites W1965608945 @default.
- W2768762471 cites W1965736135 @default.
- W2768762471 cites W1968832089 @default.
- W2768762471 cites W1968950496 @default.
- W2768762471 cites W1968999783 @default.
- W2768762471 cites W196924667 @default.
- W2768762471 cites W1970997159 @default.
- W2768762471 cites W1972121275 @default.
- W2768762471 cites W1972399884 @default.
- W2768762471 cites W1973290333 @default.
- W2768762471 cites W1974067623 @default.
- W2768762471 cites W1975708387 @default.
- W2768762471 cites W1975902897 @default.
- W2768762471 cites W1976019768 @default.
- W2768762471 cites W1978352011 @default.
- W2768762471 cites W1978486300 @default.
- W2768762471 cites W1979657493 @default.
- W2768762471 cites W1979870468 @default.
- W2768762471 cites W1981924974 @default.
- W2768762471 cites W1982049298 @default.
- W2768762471 cites W1982182361 @default.
- W2768762471 cites W1982997512 @default.
- W2768762471 cites W1984317290 @default.
- W2768762471 cites W1987143367 @default.
- W2768762471 cites W1987898313 @default.
- W2768762471 cites W1993475731 @default.
- W2768762471 cites W1995314607 @default.
- W2768762471 cites W1996131817 @default.
- W2768762471 cites W1996351611 @default.
- W2768762471 cites W2000064612 @default.
- W2768762471 cites W2001130066 @default.
- W2768762471 cites W2004964102 @default.
- W2768762471 cites W2006971960 @default.
- W2768762471 cites W2008255393 @default.
- W2768762471 cites W2010489527 @default.
- W2768762471 cites W2013947447 @default.
- W2768762471 cites W2014064723 @default.
- W2768762471 cites W2014575660 @default.
- W2768762471 cites W2019672240 @default.
- W2768762471 cites W2020628152 @default.
- W2768762471 cites W2022159627 @default.
- W2768762471 cites W2022862766 @default.
- W2768762471 cites W2025768611 @default.
- W2768762471 cites W2026102786 @default.
- W2768762471 cites W2027767870 @default.
- W2768762471 cites W2028260685 @default.
- W2768762471 cites W2029075877 @default.
- W2768762471 cites W2029089253 @default.
- W2768762471 cites W2031989207 @default.
- W2768762471 cites W2032109985 @default.
- W2768762471 cites W2032872362 @default.
- W2768762471 cites W2033409591 @default.
- W2768762471 cites W2034755731 @default.
- W2768762471 cites W2036649644 @default.
- W2768762471 cites W2041044381 @default.
- W2768762471 cites W2042908581 @default.
- W2768762471 cites W2043522659 @default.
- W2768762471 cites W2045845081 @default.
- W2768762471 cites W2048324943 @default.
- W2768762471 cites W2049201746 @default.
- W2768762471 cites W2049424828 @default.
- W2768762471 cites W2050298867 @default.
- W2768762471 cites W2052418918 @default.
- W2768762471 cites W2053497997 @default.
- W2768762471 cites W2053606962 @default.
- W2768762471 cites W2053811298 @default.
- W2768762471 cites W2055977185 @default.
- W2768762471 cites W2056381504 @default.
- W2768762471 cites W2056837963 @default.
- W2768762471 cites W2059346861 @default.
- W2768762471 cites W2062409762 @default.
- W2768762471 cites W2063358576 @default.
- W2768762471 cites W2066239225 @default.
- W2768762471 cites W2067299494 @default.
- W2768762471 cites W2068910764 @default.
- W2768762471 cites W2072798319 @default.