Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768767480> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2768767480 endingPage "6" @default.
- W2768767480 startingPage "1" @default.
- W2768767480 abstract "Background. Facial angiofibromas affect most patients with tuberous sclerosis complex. They tend to progress, can cause recurrent bleeding and facial disfigurement, and have significant psychological effects. We reviewed the effectiveness and safety of topical sirolimus ointment 0.1%. We also assessed the effect of treatment on quality of life. Methods. We report our experience in using sirolimus ointment in 14 patients with TSC (9 children and 5 adults). The impact of sirolimus ointment was monitored with digital photography, dermatological review using a validated Facial Angiofibroma Severity Index (FASI), and quality of life assessments using the questionnaires PedsQL for children and SF36 for adults. Results. The FASI scores were improved in 12/14 cases after six months’ treatment, and improvement was more likely in children (median FASI scores of improvement after treatment were 3 points for children and 1 for adults). Proxy-reported PedsQL scores for the total psychosocial domain improved significantly in the children in the cohort with treatment. Conclusions . Sirolimus ointment 0.1% administered once a day was effective in treating facial angiofibromas. It appears to be safe and well tolerated and to have a positive impact on patients’ quality of life. It appeared to be most beneficial when started in childhood." @default.
- W2768767480 created "2017-12-04" @default.
- W2768767480 creator A5021200558 @default.
- W2768767480 creator A5039472454 @default.
- W2768767480 creator A5071797740 @default.
- W2768767480 creator A5073229297 @default.
- W2768767480 date "2017-11-15" @default.
- W2768767480 modified "2023-09-28" @default.
- W2768767480 title "Sirolimus Ointment for Facial Angiofibromas in Individuals with Tuberous Sclerosis Complex" @default.
- W2768767480 cites W1523325609 @default.
- W2768767480 cites W1829835490 @default.
- W2768767480 cites W1963775558 @default.
- W2768767480 cites W1988184140 @default.
- W2768767480 cites W2002359951 @default.
- W2768767480 cites W2013808979 @default.
- W2768767480 cites W2016888102 @default.
- W2768767480 cites W2035079060 @default.
- W2768767480 cites W2035495486 @default.
- W2768767480 cites W2050790870 @default.
- W2768767480 cites W2081923349 @default.
- W2768767480 cites W2087812126 @default.
- W2768767480 cites W2113177344 @default.
- W2768767480 cites W2126467306 @default.
- W2768767480 cites W2131316359 @default.
- W2768767480 cites W2131579020 @default.
- W2768767480 cites W2136357680 @default.
- W2768767480 cites W2140896288 @default.
- W2768767480 cites W2171884143 @default.
- W2768767480 cites W2235106477 @default.
- W2768767480 cites W2517054293 @default.
- W2768767480 doi "https://doi.org/10.1155/2017/8404378" @default.
- W2768767480 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5705889" @default.
- W2768767480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29270462" @default.
- W2768767480 hasPublicationYear "2017" @default.
- W2768767480 type Work @default.
- W2768767480 sameAs 2768767480 @default.
- W2768767480 citedByCount "7" @default.
- W2768767480 countsByYear W27687674802018 @default.
- W2768767480 countsByYear W27687674802020 @default.
- W2768767480 countsByYear W27687674802021 @default.
- W2768767480 countsByYear W27687674802022 @default.
- W2768767480 crossrefType "journal-article" @default.
- W2768767480 hasAuthorship W2768767480A5021200558 @default.
- W2768767480 hasAuthorship W2768767480A5039472454 @default.
- W2768767480 hasAuthorship W2768767480A5071797740 @default.
- W2768767480 hasAuthorship W2768767480A5073229297 @default.
- W2768767480 hasBestOaLocation W27687674801 @default.
- W2768767480 hasConcept C118552586 @default.
- W2768767480 hasConcept C126322002 @default.
- W2768767480 hasConcept C141071460 @default.
- W2768767480 hasConcept C142724271 @default.
- W2768767480 hasConcept C150966472 @default.
- W2768767480 hasConcept C159110408 @default.
- W2768767480 hasConcept C16005928 @default.
- W2768767480 hasConcept C2777921159 @default.
- W2768767480 hasConcept C2778980267 @default.
- W2768767480 hasConcept C2779951463 @default.
- W2768767480 hasConcept C2781060204 @default.
- W2768767480 hasConcept C71924100 @default.
- W2768767480 hasConcept C72563966 @default.
- W2768767480 hasConceptScore W2768767480C118552586 @default.
- W2768767480 hasConceptScore W2768767480C126322002 @default.
- W2768767480 hasConceptScore W2768767480C141071460 @default.
- W2768767480 hasConceptScore W2768767480C142724271 @default.
- W2768767480 hasConceptScore W2768767480C150966472 @default.
- W2768767480 hasConceptScore W2768767480C159110408 @default.
- W2768767480 hasConceptScore W2768767480C16005928 @default.
- W2768767480 hasConceptScore W2768767480C2777921159 @default.
- W2768767480 hasConceptScore W2768767480C2778980267 @default.
- W2768767480 hasConceptScore W2768767480C2779951463 @default.
- W2768767480 hasConceptScore W2768767480C2781060204 @default.
- W2768767480 hasConceptScore W2768767480C71924100 @default.
- W2768767480 hasConceptScore W2768767480C72563966 @default.
- W2768767480 hasLocation W27687674801 @default.
- W2768767480 hasLocation W27687674802 @default.
- W2768767480 hasLocation W27687674803 @default.
- W2768767480 hasLocation W27687674804 @default.
- W2768767480 hasLocation W27687674805 @default.
- W2768767480 hasOpenAccess W2768767480 @default.
- W2768767480 hasPrimaryLocation W27687674801 @default.
- W2768767480 hasRelatedWork W2113177344 @default.
- W2768767480 hasRelatedWork W2258473985 @default.
- W2768767480 hasRelatedWork W2521224743 @default.
- W2768767480 hasRelatedWork W2742269153 @default.
- W2768767480 hasRelatedWork W2809371718 @default.
- W2768767480 hasRelatedWork W2906007117 @default.
- W2768767480 hasRelatedWork W2937245015 @default.
- W2768767480 hasRelatedWork W3002675225 @default.
- W2768767480 hasRelatedWork W3028936356 @default.
- W2768767480 hasRelatedWork W3148950155 @default.
- W2768767480 hasVolume "2017" @default.
- W2768767480 isParatext "false" @default.
- W2768767480 isRetracted "false" @default.
- W2768767480 magId "2768767480" @default.
- W2768767480 workType "article" @default.