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- W2768800571 abstract "Forkhead box C1 (FOXC1) is an essential member of the forkhead box transcription factors and has been highlighted as an important transcriptional regulator of crucial proteins associated with a wide variety of carcinomas. FOXC1 regulates tumor-associated genes and is regulated by multiple pathways that control its mRNA expression and protein activity. Aberrant FOXC1 expression is involved in diverse tumorigenic processes, such as abnormal cell proliferation, cancer stem cell maintenance, cancer migration, and angiogenesis. Herein, we review the correlation between the expression of FOXC1 and tumor behaviors. We also summarize the mechanisms of the regulation of FOXC1 expression and activity in physiological and pathological conditions. In particular, we focus on the pathological processes of cancer targeted by FOXC1 and discuss whether FOXC1 is good or detrimental during tumor progression. Moreover, FOXC1 is highlighted as a clinical biomarker for diagnosis or prognosis in various human cancers. The information reviewed here should assist in experimental designs and emphasize the potential of FOXC1 as a therapeutic target for cancer." @default.
- W2768800571 created "2017-12-04" @default.
- W2768800571 creator A5009043320 @default.
- W2768800571 creator A5010841768 @default.
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- W2768800571 creator A5018129328 @default.
- W2768800571 creator A5049692788 @default.
- W2768800571 creator A5065842255 @default.
- W2768800571 creator A5071803801 @default.
- W2768800571 creator A5089312560 @default.
- W2768800571 date "2017-11-23" @default.
- W2768800571 modified "2023-10-16" @default.
- W2768800571 title "FOXC1 in cancer development and therapy: deciphering its emerging and divergent roles" @default.
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