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- W2768823081 abstract "The incidence of lung cancer increases with age and approximately 50% of non-small cell lung cancer (NSCLC) patients are over 70 years old. Combined modality therapy is standard of care for patients with unresectable locally advanced non-small cell lung cancer (NSCLC), however, despite the multitude of clinical trials performed, elderly patients have been under-represented in these studies. Objective: To investigate outcomes for elderly patients treated with chemoradiotherapy (CRT). Patients with locally advanced stage NSCLC admitted in a tertiary hospital, between 1st January 2014 and 31st May 2016, who received CRT were selected. Patients were divided in two groups by age (<70 vs. ≥70-years old). Clinical-demographic variables, overall survival (OS) and progression free survival (PFS) were compared between the two groups. Fifty-one patients were included. The results are presented in the table:Tabled 1<70 years n=23(45,1%)≥70 years n=28(54,9%)pGenderMale[n;(%)]19(82.6)26(92.9)0.390Performance status (at diagnosis)[n;(%)]06(26.1)10(35.7)0.172116(69.6)13(46.4)21(4.3)5(17.9)Weight loss (at diagnosis)[n;(%)]0%14(60.9)16(57.1)0.8955%6(26.1)7(25.0)10%3(13.0)5(17.9)Clinical stage[n;(%)]IIIA10(43.5)17(60.7)0.070IIIB13(56.5)11(39.3)Comorbidities[n;(%)]Heart failure-4(14.8)0.076Hypertension7(30.4)20(74.1)0.002Dyslipidemia5(21.7)12(44.4)0.091Chemotherapy regimen[n;(%)]Carboplatin5(21.7)20(71.4)0.146Cisplatin18(78.3)8(28.6)CRT[n;(%)]Sequential6(26.1)11(39.3)0.320Concurrent17(73.9)17(60.7)Second line treatment[n;(%)]No16(69.6)21(75.0)0.320Yes7(30.4)7(25.0) Open table in a new tab Comparing with younger group the elderly group presented significant worse OS and longer PFS, although without statistical significance [respectively, median 7 vs. 12 months (p=0.006) and median 11.5 vs. 8 months (p=0.687)]. Elderly patients with higher PS presented worse survival (p=0.045). Patients submitted to a chemotherapy regimen with cisplatin presented better OS and PFS in both groups, although only statistical significant for the OS in patients under 70 years (p=0.023). There was no influence of other variables on OS and PFS. In our sample age was an important prognostic factor in patients submitted to CRT but other factors, as PS, also can influence prognosis. In both groups patients treated with cisplatin presented superior OS but less patients above 70 years received this treatment. Elderly patients could be considered for CRT treatment but each case should be analyzed individually. More studies are needed to guide treatment in this population." @default.
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- W2768823081 date "2017-01-01" @default.
- W2768823081 modified "2023-10-12" @default.
- W2768823081 title "P2.02-018 Chemoradiotherapy in Elderly Patients with Locally Advanced Non-Small Cell Lung Cancer" @default.
- W2768823081 doi "https://doi.org/10.1016/j.jtho.2016.11.1165" @default.
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