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- W2768836415 abstract "Glucose homeostasis is regulated by insulin, which is produced in the β-cells of the pancreas. The synthesis of insulin is controlled by several transcription factors including PDX-1, USF1 and USF2. Both, PDX-1 and USF1 were identified as substrates for protein kinase CK2. Here, we have analysed the interplay of PDX-1, USF1 and CK2 in the regulation of PDX-1 gene transcription. We found that the PDX-1 promoter is dose-dependently transactivated by PDX-1 and transrepressed by USF1. With increasing glucose concentrations the transrepression of the PDX-1 promoter by USF1 is successively abrogated. PDX-1 binding to its own promoter was not influenced by glucose, whereas USF1 binding to the PDX-1 promoter was reduced. The same effect was observed after inhibition of the protein kinase activity by three different inhibitors or by using a phospho-mutant of USF1. Moreover, phosphorylation of USF1 by CK2 seems to strengthen the interaction between USF1 and PDX-1. Thus, CK2 is a negative regulator of the USF1-dependent PDX-1 transcription. Moreover, upon inhibition of CK2 in primary islets, insulin expression as well as insulin secretion were enhanced without affecting the viability of the cells. Therefore, inhibition of CK2 activity may be a promising approach to stimulate insulin production in pancreatic β-cells." @default.
- W2768836415 created "2017-12-04" @default.
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- W2768836415 date "2017-11-27" @default.
- W2768836415 modified "2023-10-15" @default.
- W2768836415 title "Functional interplay between the transcription factors USF1 and PDX-1 and protein kinase CK2 in pancreatic β-cells" @default.
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- W2768836415 cites W1975494488 @default.
- W2768836415 cites W1975538737 @default.
- W2768836415 cites W1976943899 @default.
- W2768836415 cites W1987031617 @default.
- W2768836415 cites W1989942449 @default.
- W2768836415 cites W1990421089 @default.
- W2768836415 cites W1993148712 @default.
- W2768836415 cites W1993392404 @default.
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- W2768836415 cites W1998249838 @default.
- W2768836415 cites W2004727698 @default.
- W2768836415 cites W2004855706 @default.
- W2768836415 cites W2005894923 @default.
- W2768836415 cites W2006479619 @default.
- W2768836415 cites W2006732842 @default.
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- W2768836415 cites W2016778220 @default.
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- W2768836415 cites W2036842239 @default.
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- W2768836415 cites W2050287666 @default.
- W2768836415 cites W2052526508 @default.
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- W2768836415 cites W2057861572 @default.
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- W2768836415 cites W2063422030 @default.
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- W2768836415 doi "https://doi.org/10.1038/s41598-017-16590-0" @default.
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