Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768849313> ?p ?o ?g. }
- W2768849313 endingPage "956" @default.
- W2768849313 startingPage "944" @default.
- W2768849313 abstract "It has long been known from microneurographic recordings in human subjects that the activity of postganglionic sympathetic axons occurs as spontaneous bursts, with muscle sympathetic nerve activity (MSNA) exhibiting strong cardiac rhythmicity via the baroreflex and skin sympathetic nerve activity showing much weaker cardiac modulation. Here we review the firing properties of single sympathetic neurons, obtained using highly selective microelectrodes. Individual vasoconstrictor neurons supplying muscle or skin, or sudomotor neurons supplying sweat glands, always discharge with a low firing probability (~30%) and at very low frequencies (~0.5 Hz). Moreover, they usually fire only once per cardiac interval but can fire greater than four times within a burst. Modeling has shown that this pattern can best be explained by individual neurons being driven by, on average, two preganglionic inputs. Unitary recordings of muscle vasoconstrictor neurons have been made in several pathophysiological states, including heart failure, hypertension, obstructive sleep apnea, bronchiectasis, chronic obstructive pulmonary disease, depression, and panic disorder. The augmented MSNA in each of these diseases features an increase in firing probability and discharge frequency of individual muscle vasoconstrictor neurons above that seen in healthy subjects, yet firing rates rarely exceed 1 Hz. However, unlike patients with heart failure, all patients with respiratory disease or panic disorder, and patients with hyperhidrosis, exhibited an increase in multiple within-burst firing, which emphasizes the different modes by which the sympathetic nervous system grades its output in pathophysiological states of high sympathetic nerve activity." @default.
- W2768849313 created "2017-12-04" @default.
- W2768849313 creator A5050372398 @default.
- W2768849313 creator A5076911397 @default.
- W2768849313 date "2018-03-01" @default.
- W2768849313 modified "2023-10-02" @default.
- W2768849313 title "Physiological and pathophysiological firing properties of single postganglionic sympathetic neurons in humans" @default.
- W2768849313 cites W1492743391 @default.
- W2768849313 cites W1557642870 @default.
- W2768849313 cites W1580871265 @default.
- W2768849313 cites W1581785065 @default.
- W2768849313 cites W1729896994 @default.
- W2768849313 cites W1892742449 @default.
- W2768849313 cites W1932670697 @default.
- W2768849313 cites W1945684194 @default.
- W2768849313 cites W1964422626 @default.
- W2768849313 cites W1964562101 @default.
- W2768849313 cites W1965688106 @default.
- W2768849313 cites W1967086722 @default.
- W2768849313 cites W1969371184 @default.
- W2768849313 cites W1976289196 @default.
- W2768849313 cites W1979021656 @default.
- W2768849313 cites W1981103960 @default.
- W2768849313 cites W1982406766 @default.
- W2768849313 cites W1984113974 @default.
- W2768849313 cites W1985026594 @default.
- W2768849313 cites W1992830196 @default.
- W2768849313 cites W1995904552 @default.
- W2768849313 cites W2001261464 @default.
- W2768849313 cites W2004644362 @default.
- W2768849313 cites W2006910629 @default.
- W2768849313 cites W2010159709 @default.
- W2768849313 cites W2010385099 @default.
- W2768849313 cites W2011292063 @default.
- W2768849313 cites W2012181093 @default.
- W2768849313 cites W2015216248 @default.
- W2768849313 cites W2018796965 @default.
- W2768849313 cites W2019368014 @default.
- W2768849313 cites W2021688445 @default.
- W2768849313 cites W2022192849 @default.
- W2768849313 cites W2025889745 @default.
- W2768849313 cites W2027183896 @default.
- W2768849313 cites W2027921696 @default.
- W2768849313 cites W2031031033 @default.
- W2768849313 cites W2032060045 @default.
- W2768849313 cites W2032469993 @default.
- W2768849313 cites W2040429961 @default.
- W2768849313 cites W2040530448 @default.
- W2768849313 cites W2041616424 @default.
- W2768849313 cites W2045493233 @default.
- W2768849313 cites W2047204026 @default.
- W2768849313 cites W2047867990 @default.
- W2768849313 cites W2048556283 @default.
- W2768849313 cites W2048895026 @default.
- W2768849313 cites W2049739776 @default.
- W2768849313 cites W2052107039 @default.
- W2768849313 cites W2063158465 @default.
- W2768849313 cites W2063781207 @default.
- W2768849313 cites W2064412622 @default.
- W2768849313 cites W2066224701 @default.
- W2768849313 cites W2070004319 @default.
- W2768849313 cites W2074162473 @default.
- W2768849313 cites W2076769721 @default.
- W2768849313 cites W2078043580 @default.
- W2768849313 cites W2082305438 @default.
- W2768849313 cites W2085512316 @default.
- W2768849313 cites W2090959576 @default.
- W2768849313 cites W2092668132 @default.
- W2768849313 cites W2094766762 @default.
- W2768849313 cites W2097858723 @default.
- W2768849313 cites W2105547921 @default.
- W2768849313 cites W2108128316 @default.
- W2768849313 cites W2109229285 @default.
- W2768849313 cites W2111020812 @default.
- W2768849313 cites W2112280258 @default.
- W2768849313 cites W2114707939 @default.
- W2768849313 cites W2117086516 @default.
- W2768849313 cites W2118518615 @default.
- W2768849313 cites W2118694904 @default.
- W2768849313 cites W2120417774 @default.
- W2768849313 cites W2129873269 @default.
- W2768849313 cites W2138908243 @default.
- W2768849313 cites W2141224266 @default.
- W2768849313 cites W2143540423 @default.
- W2768849313 cites W2144315509 @default.
- W2768849313 cites W2144831147 @default.
- W2768849313 cites W2146170150 @default.
- W2768849313 cites W2150333966 @default.
- W2768849313 cites W2150759625 @default.
- W2768849313 cites W2151732051 @default.
- W2768849313 cites W2153813372 @default.
- W2768849313 cites W2159315506 @default.
- W2768849313 cites W2160581545 @default.
- W2768849313 cites W2165769260 @default.
- W2768849313 cites W2168053032 @default.
- W2768849313 cites W2169262967 @default.
- W2768849313 cites W2292059392 @default.
- W2768849313 cites W2294826991 @default.