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- W2768854512 endingPage "69" @default.
- W2768854512 startingPage "69" @default.
- W2768854512 abstract "There has been an increased interest in measuring parathyroid hormone (PTH) levels as an early predictive marker for the development of hypocalcemia after total thyroidectomy. However, significant variation exists in the timing, type of assay, and thresholds of PTH in the literature.We performed a systematic review to examine the utility of PTH levels in predicting temporary postthyroidectomy hypocalcemia.A systematic literature review of studies published prior to May 25, 2016 was performed within PubMed, EMBASE, SCOPUS, and Cochrane databases using the following terms and keywords: thyroidectomy, parathyroid hormone, and hypocalcaemia, calcium, or calcitriol. Each candidate full-text publication was reviewed by 2 independent reviewers and selected for data extraction if the study examined the prognostic significance of PTH obtained within 24 hours after thyroidectomy to predict hypocalcaemia. Studies were excluded if calcium supplementation was used routinely or based on a PTH level. Study characteristics, PTH parameters used to predict hypocalcemia, and their respective accuracies were summarized.The initial search yielded 2417 abstracts. Sixty-nine studies, comprising 9163 patients, were included. Overall, for an absolute PTH threshold, the median accuracy, sensitivity, and specificity were 86%, 85%, and 86%, respectively. For a percentage change over time the median accuracy, sensitivity, and specificity were 89%, 88%, and 90%, respectively.The existing literature regarding PTH levels to predict postthyroidectomy hypocalcemia is extremely heterogeneous. A single PTH threshold is not a reliable measure of hypocalcemia. Additional prospective studies controlled for timing of laboratory draws and a priori defined PTH thresholds need to be performed to ascertain the true prognostic significance of PTH in predicting postthyroidectomy hypocalcaemia." @default.
- W2768854512 created "2017-12-04" @default.
- W2768854512 creator A5022563459 @default.
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- W2768854512 creator A5026972135 @default.
- W2768854512 creator A5079784711 @default.
- W2768854512 creator A5083807338 @default.
- W2768854512 date "2018-01-01" @default.
- W2768854512 modified "2023-10-18" @default.
- W2768854512 title "Association of Parathyroid Hormone Level With Postthyroidectomy Hypocalcemia" @default.
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- W2768854512 doi "https://doi.org/10.1001/jamasurg.2017.3398" @default.
- W2768854512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29167863" @default.
- W2768854512 hasPublicationYear "2018" @default.
- W2768854512 type Work @default.