FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768854532> ?p ?o ?g. }

• W2768854532 abstract "Abstract The target of rapamycin (TOR) kinase assembles into two distinct multiprotein complexes, conserved across eukaryote evolution. In contrast to TOR complex 1 (TORC1), TORC2 kinase activity is not inhibited by the macrolide rapamycin. Here, we present the structure of Saccharomyces cerevisiae TORC2 determined by electron cryo-microscopy. TORC2 contains six subunits assembling into a 1.4 MDa rhombohedron. Tor2 and Lst8 form the common core of both TOR complexes. Avo3/Rictor is unique to TORC2, but interacts with the same HEAT repeats of Tor2 that are engaged by Kog1/Raptor in mammalian TORC1, explaining the mutual exclusivity of these two proteins. Density, which we conclude is Avo3, occludes the FKBP12-rapamycin-binding site of Tor2’s FRB domain rendering TORC2 rapamycin insensitive and recessing the kinase active site. Although mobile, Avo1/hSin1 further restricts access to the active site as its conserved-region-in-the-middle (CRIM) domain is positioned along an edge of the TORC2 active-site-cleft, consistent with a role for CRIM in substrate recruitment." @default.
• W2768854532 created "2017-12-04" @default.
• W2768854532 creator A5011556912 @default.
• W2768854532 creator A5013799671 @default.
• W2768854532 creator A5022759895 @default.
• W2768854532 creator A5027857523 @default.
• W2768854532 creator A5044518747 @default.
• W2768854532 creator A5053887032 @default.
• W2768854532 creator A5080919846 @default.
• W2768854532 date "2017-11-23" @default.
• W2768854532 modified "2023-10-17" @default.
• W2768854532 title "Cryo-EM structure of Saccharomyces cerevisiae target of rapamycin complex 2" @default.
• W2768854532 cites W1528321953 @default.
• W2768854532 cites W1803102843 @default.
• W2768854532 cites W1972718290 @default.
• W2768854532 cites W1973906057 @default.
• W2768854532 cites W1989641304 @default.
• W2768854532 cites W1999211774 @default.
• W2768854532 cites W2006559495 @default.
• W2768854532 cites W2016747889 @default.
• W2768854532 cites W2021557955 @default.
• W2768854532 cites W2023012828 @default.
• W2768854532 cites W2023386860 @default.
• W2768854532 cites W2048059265 @default.
• W2768854532 cites W2054770020 @default.
• W2768854532 cites W2057106513 @default.
• W2768854532 cites W2063013559 @default.
• W2768854532 cites W2064140868 @default.
• W2768854532 cites W2065887259 @default.
• W2768854532 cites W2086255954 @default.
• W2768854532 cites W2086812659 @default.
• W2768854532 cites W2087136249 @default.
• W2768854532 cites W2088908073 @default.
• W2768854532 cites W2097604487 @default.
• W2768854532 cites W2100455255 @default.
• W2768854532 cites W2101885674 @default.
• W2768854532 cites W2104234755 @default.
• W2768854532 cites W2109823034 @default.
• W2768854532 cites W2113453462 @default.
• W2768854532 cites W2114859236 @default.
• W2768854532 cites W2124026197 @default.
• W2768854532 cites W2134138119 @default.
• W2768854532 cites W2135791967 @default.
• W2768854532 cites W2142161929 @default.
• W2768854532 cites W2144059623 @default.
• W2768854532 cites W2148941629 @default.
• W2768854532 cites W2149525061 @default.
• W2768854532 cites W2152289580 @default.
• W2768854532 cites W2152562710 @default.
• W2768854532 cites W2152600551 @default.
• W2768854532 cites W2158612356 @default.
• W2768854532 cites W2161936455 @default.
• W2768854532 cites W2165393736 @default.
• W2768854532 cites W2168180694 @default.
• W2768854532 cites W2170633329 @default.
• W2768854532 cites W2180229411 @default.
• W2768854532 cites W2207318443 @default.
• W2768854532 cites W2314581397 @default.
• W2768854532 cites W2336647682 @default.
• W2768854532 cites W2345462336 @default.
• W2768854532 cites W2414012998 @default.
• W2768854532 cites W2517054293 @default.
• W2768854532 cites W2557769589 @default.
• W2768854532 cites W2568801975 @default.
• W2768854532 cites W2576890255 @default.
• W2768854532 cites W2589276620 @default.
• W2768854532 cites W2591793663 @default.
• W2768854532 cites W2593511418 @default.
• W2768854532 cites W2593816418 @default.
• W2768854532 cites W2896869836 @default.
• W2768854532 cites W2953320394 @default.
• W2768854532 cites W4244691161 @default.
• W2768854532 doi "https://doi.org/10.1038/s41467-017-01862-0" @default.
• W2768854532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5700991" @default.
• W2768854532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29170376" @default.
• W2768854532 hasPublicationYear "2017" @default.
• W2768854532 type Work @default.
• W2768854532 sameAs 2768854532 @default.
• W2768854532 citedByCount "43" @default.
• W2768854532 countsByYear W27688545322018 @default.
• W2768854532 countsByYear W27688545322019 @default.
• W2768854532 countsByYear W27688545322020 @default.
• W2768854532 countsByYear W27688545322021 @default.
• W2768854532 countsByYear W27688545322022 @default.
• W2768854532 countsByYear W27688545322023 @default.
• W2768854532 crossrefType "journal-article" @default.
• W2768854532 hasAuthorship W2768854532A5011556912 @default.
• W2768854532 hasAuthorship W2768854532A5013799671 @default.
• W2768854532 hasAuthorship W2768854532A5022759895 @default.
• W2768854532 hasAuthorship W2768854532A5027857523 @default.
• W2768854532 hasAuthorship W2768854532A5044518747 @default.
• W2768854532 hasAuthorship W2768854532A5053887032 @default.
• W2768854532 hasAuthorship W2768854532A5080919846 @default.
• W2768854532 hasBestOaLocation W27688545321 @default.
• W2768854532 hasConcept C104317684 @default.
• W2768854532 hasConcept C107824862 @default.
• W2768854532 hasConcept C141231307 @default.
• W2768854532 hasConcept C143065580 @default.
• W2768854532 hasConcept C181199279 @default.
• W2768854532 hasConcept C184235292 @default.

• next