FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768876831> ?p ?o ?g. }

• W2768876831 endingPage "454" @default.
• W2768876831 startingPage "446" @default.
• W2768876831 abstract "Thiazolidine-2,4-dione ring system is used as a pharmacophore to build various heterocyclic compounds aimed to interact with biological targets. In the present study, benzylidene-2,4-thiazolidinedione derivatives (compounds 2-5) were synthesized and screened against cancer cell lines and the genotoxicity and cytotoxicity of the most active compound (5) was investigated on normal and lung cancer cell line.For in vitro cytotoxic screening, the MTT assay was used for HL60 and K562 (leukemia), MCF-7 (breast adenocarcinoma), HT29 (colon adenocarcinoma), HEp-2 (cervix carcinoma) and NCI-H292 (lung carcinoma) tumor cell lines and Alamar-blue assay was used for non-tumor cells (PBMC, human peripheral blood mononuclear cells) were used. Cell morphology was visualized after Giemsa-May-Grunwald staining. DNA content, phosphatidylserine externalization and mitochondrial depolarization were measured by flow cytometry. Genotoxicity was assessed by Comet assay.5-(2-Bromo-5-methoxybenzylidene)-thiazolidine-2,4-dione (5) presented the most potent cytotoxicity, especially against NCI-H292 lung cancer cell line, with IC50 value of 1.26μg/mL after 72h incubation. None of the compounds were cytotoxic to PBMC. After 48h incubation, externalization of phosphatidylserine, mitochondrial depolarization, internucleosomal DNA fragmentation and morphological alterations consistent with apoptosis were observed in NCI-H292 cells treated with compound (5). In addition, compound (5) also induced genotoxicity in NCI-H292 cells (2.8-fold increase in damage index compared to the negative control), but not in PBMC.Compound 5 presented selective cytotoxic and genotoxic activity against pulmonary carcinoma (NCI-H292 cells)." @default.
• W2768876831 created "2017-12-04" @default.
• W2768876831 creator A5014228167 @default.
• W2768876831 creator A5024150951 @default.
• W2768876831 creator A5028256925 @default.
• W2768876831 creator A5035010993 @default.
• W2768876831 creator A5038812136 @default.
• W2768876831 creator A5040909721 @default.
• W2768876831 creator A5044774369 @default.
• W2768876831 creator A5047835733 @default.
• W2768876831 creator A5060776342 @default.
• W2768876831 creator A5072900879 @default.
• W2768876831 creator A5078258358 @default.
• W2768876831 date "2018-06-01" @default.
• W2768876831 modified "2023-09-26" @default.
• W2768876831 title "Selective cytotoxic and genotoxic activities of 5-(2-bromo-5-methoxybenzylidene)-thiazolidine-2,4-dione against NCI-H292 human lung carcinoma cells" @default.
• W2768876831 cites W1975757666 @default.
• W2768876831 cites W1981214567 @default.
• W2768876831 cites W1997219075 @default.
• W2768876831 cites W2003066201 @default.
• W2768876831 cites W2010085580 @default.
• W2768876831 cites W2016446817 @default.
• W2768876831 cites W2034485370 @default.
• W2768876831 cites W2034915619 @default.
• W2768876831 cites W2037323330 @default.
• W2768876831 cites W2052853635 @default.
• W2768876831 cites W2059945861 @default.
• W2768876831 cites W2061651475 @default.
• W2768876831 cites W2092629964 @default.
• W2768876831 cites W2094907955 @default.
• W2768876831 cites W2106134152 @default.
• W2768876831 cites W2114918609 @default.
• W2768876831 cites W2117692326 @default.
• W2768876831 cites W2122959256 @default.
• W2768876831 cites W2136427955 @default.
• W2768876831 cites W2148749467 @default.
• W2768876831 cites W2154385453 @default.
• W2768876831 cites W2162194005 @default.
• W2768876831 cites W2335039519 @default.
• W2768876831 cites W2463981086 @default.
• W2768876831 cites W2477412563 @default.
• W2768876831 cites W2598125535 @default.
• W2768876831 cites W2952709614 @default.
• W2768876831 doi "https://doi.org/10.1016/j.pharep.2017.11.008" @default.
• W2768876831 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29627691" @default.
• W2768876831 hasPublicationYear "2018" @default.
• W2768876831 type Work @default.
• W2768876831 sameAs 2768876831 @default.
• W2768876831 citedByCount "11" @default.
• W2768876831 countsByYear W27688768312019 @default.
• W2768876831 countsByYear W27688768312020 @default.
• W2768876831 countsByYear W27688768312021 @default.
• W2768876831 countsByYear W27688768312022 @default.
• W2768876831 crossrefType "journal-article" @default.
• W2768876831 hasAuthorship W2768876831A5014228167 @default.
• W2768876831 hasAuthorship W2768876831A5024150951 @default.
• W2768876831 hasAuthorship W2768876831A5028256925 @default.
• W2768876831 hasAuthorship W2768876831A5035010993 @default.
• W2768876831 hasAuthorship W2768876831A5038812136 @default.
• W2768876831 hasAuthorship W2768876831A5040909721 @default.
• W2768876831 hasAuthorship W2768876831A5044774369 @default.
• W2768876831 hasAuthorship W2768876831A5047835733 @default.
• W2768876831 hasAuthorship W2768876831A5060776342 @default.
• W2768876831 hasAuthorship W2768876831A5072900879 @default.
• W2768876831 hasAuthorship W2768876831A5078258358 @default.
• W2768876831 hasBestOaLocation W27688768312 @default.
• W2768876831 hasConcept C109316439 @default.
• W2768876831 hasConcept C121608353 @default.
• W2768876831 hasConcept C143425029 @default.
• W2768876831 hasConcept C153911025 @default.
• W2768876831 hasConcept C154317977 @default.
• W2768876831 hasConcept C178790620 @default.
• W2768876831 hasConcept C185592680 @default.
• W2768876831 hasConcept C190283241 @default.
• W2768876831 hasConcept C202751555 @default.
• W2768876831 hasConcept C2778903051 @default.
• W2768876831 hasConcept C2778959862 @default.
• W2768876831 hasConcept C2780358455 @default.
• W2768876831 hasConcept C29730261 @default.
• W2768876831 hasConcept C31573885 @default.
• W2768876831 hasConcept C43759708 @default.
• W2768876831 hasConcept C502942594 @default.
• W2768876831 hasConcept C54355233 @default.
• W2768876831 hasConcept C552990157 @default.
• W2768876831 hasConcept C55493867 @default.
• W2768876831 hasConcept C81885089 @default.
• W2768876831 hasConcept C86803240 @default.
• W2768876831 hasConcept C96232424 @default.
• W2768876831 hasConceptScore W2768876831C109316439 @default.
• W2768876831 hasConceptScore W2768876831C121608353 @default.
• W2768876831 hasConceptScore W2768876831C143425029 @default.
• W2768876831 hasConceptScore W2768876831C153911025 @default.
• W2768876831 hasConceptScore W2768876831C154317977 @default.
• W2768876831 hasConceptScore W2768876831C178790620 @default.
• W2768876831 hasConceptScore W2768876831C185592680 @default.
• W2768876831 hasConceptScore W2768876831C190283241 @default.
• W2768876831 hasConceptScore W2768876831C202751555 @default.
• W2768876831 hasConceptScore W2768876831C2778903051 @default.

• next