Matches in SemOpenAlex for { <https://semopenalex.org/work/W2768917865> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2768917865 abstract "Control methods to reduce exposure to the fumonisin carcinogens in maize are critical, especially in rural subsistence populations at an increased risk. The fumonisins are a group of mycotoxins mainly produced by Fusarium spp. They are hepatocarcinogenic to rodents, and have been associated with oesophageal and liver cancer in subsistence maize farming communities around the world. The intact molecule and the free amino group determine the cancer-initiating activity, while the carballylic acid moiety plays an active role in absorption of the fumonisins from the gut. Fumonisin B1 (FB1) is the most abundant naturally occurring fumonisin on maize and maize-based food worldwide and is classified as a Group 2B carcinogen by the International Agency for Research on Cancer (IARC). The Joint FAO/WHO Expert Committee on Food Additives (JECFA) has determined a group provisional maximum tolerable daily intake (PMTDI) for FB1, FB2, and FB3, alone or in combination, of 2 µg/kg body weight/day. In many Sub-Saharan countries, where both maize contamination and maize consumption are high, regulatory mechanisms to control mycotoxin levels, including fumonisin, are either lacking or are not enforced. Therefore, reducing exposure levels by interventions, specifically those based on simple low-cost measures acceptable to these communities, becomes relevant. Although certain physical and chemical methods for control of Fusarium diseases and the fumonsins in maize are currently applied, there are several concerns with regards to the health, safety and environmental risks. Biologically based methods are increasingly being explored, including several approaches pre-harvest (breeding for resistant maize cultivars; introduction of biocontrol microorganisms; application of phenolic plant extracts; expression of antifungal proteins and fumonisin degrading enzymes in transgenic maize cultivars). Postharvest approaches include removal of fumonisins from food by natural clay adsorbents and enzymatic degradation of fumonisins through decarboxylation and deamination by recombinant carboxylesterase and aminotransferase enzymes. This paper will discuss biologically based control methods with special emphasis on the development of food-grade recombinant enzymes and its possible application during the conditioning stage of commercial dry milling of maize. Cultural specific and simple intervention strategies for introduction of these methods to rural communities at risk will also be discussed. Biologically based approaches could be beneficial as control measure to reduce exposure of populations exposed to high levels of this carcinogen. Citation Format: Johanna Francina Alberts, Willem Heber Van Zyl, Wentzel Christoffel Gelderblom. Biological approaches for reducing fumonisin carcinogens in maize [abstract]. In: Proceedings of the AACR International Conference: New Frontiers in Cancer Research; 2017 Jan 18-22; Cape Town, South Africa. Philadelphia (PA): AACR; Cancer Res 2017;77(22 Suppl):Abstract nr B24." @default.
- W2768917865 created "2017-12-04" @default.
- W2768917865 creator A5043569276 @default.
- W2768917865 creator A5054863324 @default.
- W2768917865 creator A5070199645 @default.
- W2768917865 date "2017-11-14" @default.
- W2768917865 modified "2023-09-26" @default.
- W2768917865 title "Abstract B24: Biological approaches for reducing fumonisin carcinogens in maize" @default.
- W2768917865 doi "https://doi.org/10.1158/1538-7445.newfront17-b24" @default.
- W2768917865 hasPublicationYear "2017" @default.
- W2768917865 type Work @default.
- W2768917865 sameAs 2768917865 @default.
- W2768917865 citedByCount "0" @default.
- W2768917865 crossrefType "proceedings-article" @default.
- W2768917865 hasAuthorship W2768917865A5043569276 @default.
- W2768917865 hasAuthorship W2768917865A5054863324 @default.
- W2768917865 hasAuthorship W2768917865A5070199645 @default.
- W2768917865 hasConcept C114246631 @default.
- W2768917865 hasConcept C118518473 @default.
- W2768917865 hasConcept C134018914 @default.
- W2768917865 hasConcept C144027150 @default.
- W2768917865 hasConcept C147583825 @default.
- W2768917865 hasConcept C150903083 @default.
- W2768917865 hasConcept C156005406 @default.
- W2768917865 hasConcept C18903297 @default.
- W2768917865 hasConcept C2776657025 @default.
- W2768917865 hasConcept C2778431908 @default.
- W2768917865 hasConcept C2778867309 @default.
- W2768917865 hasConcept C2781429003 @default.
- W2768917865 hasConcept C33070731 @default.
- W2768917865 hasConcept C55493867 @default.
- W2768917865 hasConcept C84699730 @default.
- W2768917865 hasConcept C86803240 @default.
- W2768917865 hasConceptScore W2768917865C114246631 @default.
- W2768917865 hasConceptScore W2768917865C118518473 @default.
- W2768917865 hasConceptScore W2768917865C134018914 @default.
- W2768917865 hasConceptScore W2768917865C144027150 @default.
- W2768917865 hasConceptScore W2768917865C147583825 @default.
- W2768917865 hasConceptScore W2768917865C150903083 @default.
- W2768917865 hasConceptScore W2768917865C156005406 @default.
- W2768917865 hasConceptScore W2768917865C18903297 @default.
- W2768917865 hasConceptScore W2768917865C2776657025 @default.
- W2768917865 hasConceptScore W2768917865C2778431908 @default.
- W2768917865 hasConceptScore W2768917865C2778867309 @default.
- W2768917865 hasConceptScore W2768917865C2781429003 @default.
- W2768917865 hasConceptScore W2768917865C33070731 @default.
- W2768917865 hasConceptScore W2768917865C55493867 @default.
- W2768917865 hasConceptScore W2768917865C84699730 @default.
- W2768917865 hasConceptScore W2768917865C86803240 @default.
- W2768917865 hasLocation W27689178651 @default.
- W2768917865 hasOpenAccess W2768917865 @default.
- W2768917865 hasPrimaryLocation W27689178651 @default.
- W2768917865 hasRelatedWork W129434021 @default.
- W2768917865 hasRelatedWork W134888174 @default.
- W2768917865 hasRelatedWork W1979006706 @default.
- W2768917865 hasRelatedWork W1998235953 @default.
- W2768917865 hasRelatedWork W2064889455 @default.
- W2768917865 hasRelatedWork W2163695962 @default.
- W2768917865 hasRelatedWork W2326257086 @default.
- W2768917865 hasRelatedWork W2771080098 @default.
- W2768917865 hasRelatedWork W2789363951 @default.
- W2768917865 hasRelatedWork W2913087307 @default.
- W2768917865 hasRelatedWork W2938455801 @default.
- W2768917865 hasRelatedWork W2943596036 @default.
- W2768917865 hasRelatedWork W2972650583 @default.
- W2768917865 hasRelatedWork W3008595432 @default.
- W2768917865 hasRelatedWork W3021904047 @default.
- W2768917865 hasRelatedWork W3023858135 @default.
- W2768917865 hasRelatedWork W3180856806 @default.
- W2768917865 hasRelatedWork W322918666 @default.
- W2768917865 hasRelatedWork W926402522 @default.
- W2768917865 hasRelatedWork W934966988 @default.
- W2768917865 isParatext "false" @default.
- W2768917865 isRetracted "false" @default.
- W2768917865 magId "2768917865" @default.
- W2768917865 workType "article" @default.