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- W2768923003 abstract "Human brain imaging studies have revealed the anterior cingulate cortex (ACC) as a key brain region for mediating visceral-pain-cognitive interactions. Recently, we characterized impairments of long-term potentiation and spike-field coherence in the basolateral amygdala (BLA)-ACC network in association with a decision-making deficit in rats with visceral hypersensitivity (VH). Now, by combining integrative neurobiological approaches, we show that ACC-reactive astrogliosis and activity-dependent impairment of lactate release occur in VH rats. Exogenous lactate supply rescues chronic-visceral-pain-caused impairments of ACC phase locking and decision making, which can be mimicked by optogenetic activation of ACC astrocytes. Large-scale electrophysiological recordings in free-moving animals during a decision-making task indicate that optogenetic astrocytic activation improves decision-making performance and engages ACC phase locking and BLA-to-ACC information flow. Collectively, these observations support the idea of an astrocyte-neuron l-lactate shuttle and suggest that targeting astrocytes may help with cognitive dysfunctions under chronic visceral pain." @default.
- W2768923003 created "2017-12-04" @default.
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- W2768923003 date "2017-11-01" @default.
- W2768923003 modified "2023-10-09" @default.
- W2768923003 title "Astrocytic l -Lactate Signaling Facilitates Amygdala-Anterior Cingulate Cortex Synchrony and Decision Making in Rats" @default.
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- W2768923003 doi "https://doi.org/10.1016/j.celrep.2017.11.012" @default.
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