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- W2768923998 abstract "Neuroinflammation is a hallmark of human epileptogenic foci in various pharmacoresistant forms of epilepsy. Increasing experimental evidence has shown that neuroinflammation is not a bystander phenomenon of the diseased brain tissue, but it contributes to neuronal hyperexcitability underlying seizure generation. Several of the molecules that constitute the inflammatory milieu in the epileptogenic areas can activate signaling pathways in neurons and glia that result in pathologic modifications of cell function. These pathways include rapid posttranslational changes in voltage-gated and receptor-coupled ion channels, mostly mediated by activation of protein kinases, and transcriptional regulation of genes involved in synaptic transmission and plasticity. These nonconventional modes of action highlight the neuromodulatory role of inflammatory molecules, which differs from their classic functions as mediators of immune activation during infections." @default.
- W2768923998 created "2017-12-04" @default.
- W2768923998 creator A5040671001 @default.
- W2768923998 creator A5064331000 @default.
- W2768923998 creator A5070101998 @default.
- W2768923998 date "2018-01-01" @default.
- W2768923998 modified "2023-09-26" @default.
- W2768923998 title "Ictogenic and Epileptogenic Mechanisms of Neuroinflammation" @default.
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- W2768923998 doi "https://doi.org/10.1016/b978-0-323-53088-0.00004-x" @default.
- W2768923998 hasPublicationYear "2018" @default.