FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769064098> ?p ?o ?g. }

• W2769064098 endingPage "291" @default.
• W2769064098 startingPage "283" @default.
• W2769064098 abstract "Agnathans have a globin repertoire that markedly differs from that of jawed (gnathostome) vertebrates. The sea lamprey (Petromyzon marinus) harbors at least 18 hemoglobin, two myoglobin, two globin X, and one cytoglobin genes. However, agnathan hemoglobins and myoglobins are not orthologous to their cognates in jawed vertebrates. Thus, blood-based O2 transport and muscle-based O2 storage proteins emerged twice in vertebrates from a tissue-globin ancestor. Notably, the sea lamprey displays three switches in hemoglobin expression in its life cycle, analogous to hemoglobin switching in vertebrates. To study the functional changes associated with the evolution and ontogenesis of distinct globin types, we determined O2 binding equilibria, type of quaternary assembly, and nitrite reductase enzymatic activities of one adult (aHb5a) and one embryonic/larval hemoglobin (aHb6), myoglobin (aMb1) and cytoglobin (Cygb) of the sea lamprey. We found clear functional differentiation among globin types expressed at different developmental stages and in different tissues. Cygb and aMb1 have high O2 affinity and nitrite reductase activity, while the two hemoglobins display low O2 affinity and nitrite reductase activity. Cygb and aHb6 but not aHb5a show cooperative O2 binding, correlating with increased stability of dimers, as shown by gel filtration and molecular modeling. The high O2-affinity and the lack of cooperativity confirm the identity of the sea lamprey aMb1 as O2 storage protein of the muscle. The dimeric structure and O2-binding properties of sea lamprey and mammalian Cygb were very similar, suggesting a conservation of function since their divergence around 500million years ago." @default.
• W2769064098 created "2017-12-04" @default.
• W2769064098 creator A5005938435 @default.
• W2769064098 creator A5018247144 @default.
• W2769064098 creator A5034685316 @default.
• W2769064098 creator A5041477250 @default.
• W2769064098 creator A5057618777 @default.
• W2769064098 date "2018-02-01" @default.
• W2769064098 modified "2023-09-24" @default.
• W2769064098 title "Functional diversification of sea lamprey globins in evolution and development" @default.
• W2769064098 cites W1530231574 @default.
• W2769064098 cites W1589677189 @default.
• W2769064098 cites W1653986885 @default.
• W2769064098 cites W1935776831 @default.
• W2769064098 cites W1969133067 @default.
• W2769064098 cites W1970679552 @default.
• W2769064098 cites W1974297725 @default.
• W2769064098 cites W1975719907 @default.
• W2769064098 cites W1977834892 @default.
• W2769064098 cites W1980608095 @default.
• W2769064098 cites W1981082470 @default.
• W2769064098 cites W1987664969 @default.
• W2769064098 cites W1988936361 @default.
• W2769064098 cites W1996591545 @default.
• W2769064098 cites W2002637396 @default.
• W2769064098 cites W2005216066 @default.
• W2769064098 cites W2007723987 @default.
• W2769064098 cites W2018252877 @default.
• W2769064098 cites W2026836635 @default.
• W2769064098 cites W2030796996 @default.
• W2769064098 cites W2031122915 @default.
• W2769064098 cites W2032466859 @default.
• W2769064098 cites W2033357754 @default.
• W2769064098 cites W2036519312 @default.
• W2769064098 cites W2037967237 @default.
• W2769064098 cites W2043209324 @default.
• W2769064098 cites W2043243758 @default.
• W2769064098 cites W2050123648 @default.
• W2769064098 cites W2059626889 @default.
• W2769064098 cites W2071401650 @default.
• W2769064098 cites W2072115406 @default.
• W2769064098 cites W2072307990 @default.
• W2769064098 cites W2073301864 @default.
• W2769064098 cites W2074473216 @default.
• W2769064098 cites W2080725398 @default.
• W2769064098 cites W2080962839 @default.
• W2769064098 cites W2081912151 @default.
• W2769064098 cites W2092710202 @default.
• W2769064098 cites W2096118264 @default.
• W2769064098 cites W2109549801 @default.
• W2769064098 cites W2114334714 @default.
• W2769064098 cites W2122902308 @default.
• W2769064098 cites W2124772083 @default.
• W2769064098 cites W2126914807 @default.
• W2769064098 cites W2134281271 @default.
• W2769064098 cites W2141182699 @default.
• W2769064098 cites W2141647955 @default.
• W2769064098 cites W2143317165 @default.
• W2769064098 cites W2151878757 @default.
• W2769064098 cites W2155926377 @default.
• W2769064098 cites W2179672741 @default.
• W2769064098 cites W2250364644 @default.
• W2769064098 cites W2253332193 @default.
• W2769064098 cites W23156506 @default.
• W2769064098 cites W2315732880 @default.
• W2769064098 cites W2567489333 @default.
• W2769064098 cites W4252592659 @default.
• W2769064098 doi "https://doi.org/10.1016/j.bbapap.2017.11.009" @default.
• W2769064098 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29155105" @default.
• W2769064098 hasPublicationYear "2018" @default.
• W2769064098 type Work @default.
• W2769064098 sameAs 2769064098 @default.
• W2769064098 citedByCount "9" @default.
• W2769064098 countsByYear W27690640982018 @default.
• W2769064098 countsByYear W27690640982019 @default.
• W2769064098 countsByYear W27690640982020 @default.
• W2769064098 countsByYear W27690640982021 @default.
• W2769064098 countsByYear W27690640982023 @default.
• W2769064098 crossrefType "journal-article" @default.
• W2769064098 hasAuthorship W2769064098A5005938435 @default.
• W2769064098 hasAuthorship W2769064098A5018247144 @default.
• W2769064098 hasAuthorship W2769064098A5034685316 @default.
• W2769064098 hasAuthorship W2769064098A5041477250 @default.
• W2769064098 hasAuthorship W2769064098A5057618777 @default.
• W2769064098 hasConcept C104317684 @default.
• W2769064098 hasConcept C125996951 @default.
• W2769064098 hasConcept C181199279 @default.
• W2769064098 hasConcept C2776318716 @default.
• W2769064098 hasConcept C2777343278 @default.
• W2769064098 hasConcept C2778063876 @default.
• W2769064098 hasConcept C2778710519 @default.
• W2769064098 hasConcept C2778917026 @default.
• W2769064098 hasConcept C2778961482 @default.
• W2769064098 hasConcept C2780417240 @default.
• W2769064098 hasConcept C2781341435 @default.
• W2769064098 hasConcept C2909643359 @default.
• W2769064098 hasConcept C505870484 @default.
• W2769064098 hasConcept C55493867 @default.

• next