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• W2769069311 endingPage "e1408746" @default.
• W2769069311 startingPage "e1408746" @default.
• W2769069311 abstract "Aggressive forms of breast cancer, such as Her2+ and triple negative breast cancer (TNBC), are enriched in breast cancer stem cells (BCSC) and have limited therapeutic options. BCSC represent a key cellular reservoir for relapse, metastatic progression and therapeutic resistance. Their ability to resist common cytotoxic therapies relies on different mechanisms, including improved detoxification. The cystine-glutamate antiporter protein xCT (SLC7A11) regulates cystine intake, conversion to cysteine and subsequent glutathione synthesis, protecting cells against oxidative and chemical insults. Our previous work showed that xCT is highly expressed in tumorspheres derived from breast cancer cell lines and downregulation of xCT altered BCSC function in vitro and inhibited pulmonary metastases in vivo. We further strengthened these observations by developing a virus-like-particle (VLP; AX09-0M6) immunotherapy targeting the xCT protein. AX09-0M6 elicited a strong antibody response against xCT including high levels of IgG2a antibody. IgG isolated from AX09-0M6 treated mice bound to tumorspheres, inhibited xCT function as assessed by reactive oxygen species generation and decreased BCSC growth and self-renewal. To assess if AX09-0M6 impacts BCSC in vivo seeding, Her2+ TUBO-derived tumorspheres were injected into the tail vein of AX09-0M6 or control treated female BALB/c mice. AX09-0M6 significantly inhibited formation of pulmonary nodules. To evaluate its ability to impact metastases, AX09-0M6 was administered to mice with established subcutaneous 4T1 tumors. AX09-0M6 administration significantly hampered tumor growth and development of pulmonary metastases. These data show that a VLP-based immunization approach inhibits xCT activity, impacts BCSC biology and significantly reduces metastatic progression in preclinical models." @default.
• W2769069311 created "2017-12-04" @default.
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• W2769069311 date "2017-12-06" @default.
• W2769069311 modified "2023-10-01" @default.
• W2769069311 title "A Virus-Like-Particle immunotherapy targeting Epitope-Specific anti-xCT expressed on cancer stem cell inhibits the progression of metastatic cancer<i>in vivo</i>" @default.
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• W2769069311 cites W1972698949 @default.
• W2769069311 cites W1975983467 @default.
• W2769069311 cites W1980714336 @default.
• W2769069311 cites W1980932672 @default.
• W2769069311 cites W1984330519 @default.
• W2769069311 cites W1985558623 @default.
• W2769069311 cites W1991701295 @default.
• W2769069311 cites W1999356404 @default.
• W2769069311 cites W2000087607 @default.
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• W2769069311 cites W2009029469 @default.
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• W2769069311 cites W2041399911 @default.
• W2769069311 cites W2042890278 @default.
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• W2769069311 doi "https://doi.org/10.1080/2162402x.2017.1408746" @default.
• W2769069311 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5790338" @default.
• W2769069311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29399412" @default.
• W2769069311 hasPublicationYear "2017" @default.
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