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- W2769085236 endingPage "R25" @default.
- W2769085236 startingPage "R1" @default.
- W2769085236 abstract "Molecular targeted therapy of advanced neuroendocrine tumours (NETs) of the gastroenteropancreatic (GEP) system currently encompasses approved therapy with the mammalian target of rapamycin (mTOR) inhibitor everolimus and the multi-tyrosinkinase inhibitor sunitinib. However, clinical efficacy of these treatment strategies is limited by low objective response rates and limited progression-free survival due to tumour resistance. Further novel strategies for molecular targeted therapy of NETs of the GEP system are needed. This paper reviews preclinical research models and signalling pathways in NETs of the GEP system. Preclinical and early clinical data on putative novel targets for molecular targeted therapy of NETs of the GEP system are discussed, including PI3K, Akt, mTORC1/mTORC2, GSK3, c-Met, Ras–Raf–MEK–ERK, embryogenic pathways (Hedgehog, Notch, Wnt/beta-catenin, TGF-beta signalling and SMAD proteins), tumour suppressors and cell cycle regulators (p53, cyclin-dependent kinases (CDKs) CDK4/6, CDK inhibitor p27, retinoblastoma protein (Rb)), heat shock protein HSP90, Aurora kinase, Src kinase family, focal adhesion kinase and epigenetic modulation by histone deacetylase inhibitors." @default.
- W2769085236 created "2017-12-04" @default.
- W2769085236 creator A5019842412 @default.
- W2769085236 creator A5075406960 @default.
- W2769085236 date "2018-01-01" @default.
- W2769085236 modified "2023-10-05" @default.
- W2769085236 title "Targeted therapy of gastroenteropancreatic neuroendocrine tumours: preclinical strategies and future targets" @default.
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