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- W2769114963 endingPage "12637" @default.
- W2769114963 startingPage "12625" @default.
- W2769114963 abstract "Most proteins involved in the DNA double-strand break response (DSBR) accumulate at the damage sites, where they perform functions related to damage signaling, chromatin remodeling and repair. Over the last two decades, studying the accumulation of many DSBR proteins provided information about their functionality and underlying mechanisms of action. However, comparison and systemic interpretation of these data is challenging due to their scattered nature and differing experimental approaches. Here, we extracted, analyzed and compared the available results describing accumulation of 79 DSBR proteins at sites of DNA damage, which can be further explored using Cumulus (http://www.dna-repair.live/cumulus/)—the accompanying interactive online application. Despite large inter-study variability, our analysis revealed that the accumulation of most proteins starts immediately after damage induction, occurs in parallel and peaks within 15–20 min. Various DSBR pathways are characterized by distinct accumulation kinetics with major non-homologous end joining proteins being generally faster than those involved in homologous recombination, and signaling and chromatin remodeling factors accumulating with varying speeds. Our meta-analysis provides, for the first time, comprehensive overview of the temporal organization of the DSBR in mammalian cells and could serve as a reference for future mechanistic studies of this complex process." @default.
- W2769114963 created "2017-12-04" @default.
- W2769114963 creator A5051025539 @default.
- W2769114963 creator A5051072406 @default.
- W2769114963 creator A5071336077 @default.
- W2769114963 creator A5074726445 @default.
- W2769114963 creator A5076262911 @default.
- W2769114963 creator A5080870892 @default.
- W2769114963 creator A5091679060 @default.
- W2769114963 date "2017-11-22" @default.
- W2769114963 modified "2023-10-15" @default.
- W2769114963 title "Meta-analysis of DNA double-strand break response kinetics" @default.
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