FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769124474> ?p ?o ?g. }

• W2769124474 endingPage "13717" @default.
• W2769124474 startingPage "13708" @default.
• W2769124474 abstract "Poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC), when end-tethered to surfaces by the adsorption of copolymeric cationic segments, forms adsorbed layers that substantially reduce protein adsorption. This study examined variations in the molecular architecture of copolymers containing cationic poly(trimethylammonium ethyl methacrylate (pTMAEMA) anchor blocks that adsorbed strongly to negative surfaces. With appropriate copolymer design, the pTMAEMA blocks were shielded, by pMPC tethers, from solution-phase proteins. The most protein-resistant copolymer layers, eliminating fibrinogen and lysozyme adsorption within detectible limits of 0.01 mg/m2, had metrics (the amount of pMPC at the surface and the reduced tether footprint) consistent with the formation of an interfacial polymer brush. The p(TMAEMA-b-MPC) copolymer layers substantially outperformed the protein resistance of surface-polymerized pMPC layers when compared on a per-polyzwitterion-mass basis or on the basis of the scaled tether area. Additionally, p(TMAEMA-b-MPC) copolymer layers offered advantages over the much-studied cationically anchored poly(ethylene glycol) (PEG) graft copolymer system, which forms PEG brushes by the adsorption of a poly l-lysine (PLL) backbone. Although the optimized p(TMAEMA-b-MPC) and PLL-PEG copolymers were similarly fibrinogen-resistant, the cationic protein lysozyme was repelled by pMPC but adhered to the PEG brush via PEG-lysozyme attractions. Additionally, the adsorbed p(TMAEMA-b-MPC) copolymers were not displaced by poly l-lysine homopolymers, which completely displaced the PLL-PEG copolymer to expose a protein-adhesive surface. Thus, the p(TMAEMA-b-MPC) copolymer system comprises a scalable means to produce protein-repellent surfaces, free of the complexities of surface-initiated polymerization and with the advantages of polyzwitterions." @default.
• W2769124474 created "2017-12-04" @default.
• W2769124474 creator A5030195131 @default.
• W2769124474 creator A5042356436 @default.
• W2769124474 creator A5056955607 @default.
• W2769124474 creator A5062460309 @default.
• W2769124474 date "2017-11-14" @default.
• W2769124474 modified "2023-10-17" @default.
• W2769124474 title "Adsorbed Polyzwitterion Copolymer Layers Designed for Protein Repellency and Interfacial Retention" @default.
• W2769124474 cites W1036119305 @default.
• W2769124474 cites W1899130781 @default.
• W2769124474 cites W1967523484 @default.
• W2769124474 cites W1969168513 @default.
• W2769124474 cites W1970110933 @default.
• W2769124474 cites W1972539574 @default.
• W2769124474 cites W1977040267 @default.
• W2769124474 cites W1981028296 @default.
• W2769124474 cites W1982967478 @default.
• W2769124474 cites W1987378825 @default.
• W2769124474 cites W1989913459 @default.
• W2769124474 cites W1992528022 @default.
• W2769124474 cites W1996073717 @default.
• W2769124474 cites W2005037415 @default.
• W2769124474 cites W2008303284 @default.
• W2769124474 cites W2020038404 @default.
• W2769124474 cites W2026762137 @default.
• W2769124474 cites W2036133979 @default.
• W2769124474 cites W2040576110 @default.
• W2769124474 cites W2044540813 @default.
• W2769124474 cites W2045260522 @default.
• W2769124474 cites W2045691265 @default.
• W2769124474 cites W2046126941 @default.
• W2769124474 cites W2050332277 @default.
• W2769124474 cites W2054757473 @default.
• W2769124474 cites W2056677626 @default.
• W2769124474 cites W2058374592 @default.
• W2769124474 cites W2060741871 @default.
• W2769124474 cites W2062832237 @default.
• W2769124474 cites W2064788332 @default.
• W2769124474 cites W2067425434 @default.
• W2769124474 cites W2073186779 @default.
• W2769124474 cites W2077050947 @default.
• W2769124474 cites W2090393275 @default.
• W2769124474 cites W2090750082 @default.
• W2769124474 cites W2092415206 @default.
• W2769124474 cites W2107766241 @default.
• W2769124474 cites W2120257336 @default.
• W2769124474 cites W2121263864 @default.
• W2769124474 cites W2131414785 @default.
• W2769124474 cites W2165268405 @default.
• W2769124474 cites W2172156072 @default.
• W2769124474 cites W2213554974 @default.
• W2769124474 cites W2312441021 @default.
• W2769124474 cites W2313277816 @default.
• W2769124474 cites W2321719068 @default.
• W2769124474 cites W2323548304 @default.
• W2769124474 cites W2340432140 @default.
• W2769124474 cites W2342793245 @default.
• W2769124474 cites W2424693082 @default.
• W2769124474 cites W2562878337 @default.
• W2769124474 cites W2617130277 @default.
• W2769124474 cites W4238419171 @default.
• W2769124474 cites W437228581 @default.
• W2769124474 cites W71689619 @default.
• W2769124474 cites W848448822 @default.
• W2769124474 cites W985078251 @default.
• W2769124474 cites W1965670335 @default.
• W2769124474 doi "https://doi.org/10.1021/acs.langmuir.7b03391" @default.
• W2769124474 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29134801" @default.
• W2769124474 hasPublicationYear "2017" @default.
• W2769124474 type Work @default.
• W2769124474 sameAs 2769124474 @default.
• W2769124474 citedByCount "18" @default.
• W2769124474 countsByYear W27691244742018 @default.
• W2769124474 countsByYear W27691244742019 @default.
• W2769124474 countsByYear W27691244742020 @default.
• W2769124474 countsByYear W27691244742021 @default.
• W2769124474 countsByYear W27691244742022 @default.
• W2769124474 countsByYear W27691244742023 @default.
• W2769124474 crossrefType "journal-article" @default.
• W2769124474 hasAuthorship W2769124474A5030195131 @default.
• W2769124474 hasAuthorship W2769124474A5042356436 @default.
• W2769124474 hasAuthorship W2769124474A5056955607 @default.
• W2769124474 hasAuthorship W2769124474A5062460309 @default.
• W2769124474 hasConcept C10138342 @default.
• W2769124474 hasConcept C127413603 @default.
• W2769124474 hasConcept C132050475 @default.
• W2769124474 hasConcept C150394285 @default.
• W2769124474 hasConcept C15920480 @default.
• W2769124474 hasConcept C162324750 @default.
• W2769124474 hasConcept C178790620 @default.
• W2769124474 hasConcept C183882617 @default.
• W2769124474 hasConcept C185592680 @default.
• W2769124474 hasConcept C188027245 @default.
• W2769124474 hasConcept C188109995 @default.
• W2769124474 hasConcept C192562407 @default.
• W2769124474 hasConcept C2776966407 @default.
• W2769124474 hasConcept C2777516009 @default.

• next