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- W2769151330 abstract "BACKGROUND Alloimmunization through blood transfusion, transplantation, or circulating fetal cells during pregnancy is a significant concern. Some exposed individuals make alloantibodies while others do not, implying variation in genetic risk factors. STUDY DESIGN AND METHODS We conducted a genomewide association study (GWAS) of 9,427,497 single‐nucleotide polymorphisms (SNPs) to identify genetic variants for HLA alloimmunization in previously pregnant blood donors with (n = 752) and without (n = 753) HLA Class I or II alloantibodies. RESULTS A SNP in the neurexophilin 2 (NXPH2) gene surpassed genome‐wide significance (p = 2.06 × 10 −8 ), with multiple adjacent markers p < 10 −6 , for women with anti‐Class I alloantibodies only. Little is currently known about the function of NXPH2, although gene family members have been shown to impact immunity. SNPs in the E2F7 gene, a transcription factor related to cell cycle control and cellular proliferation, also approached genomewide significance (p = 2.5 × 10 −7 ). CONCLUSION Further work to extend the GWAS approach and to characterize variants in NXPH2 and E2F7 in the context of alloantibody formation is warranted." @default.
- W2769151330 created "2017-12-04" @default.
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- W2769151330 date "2017-11-22" @default.
- W2769151330 modified "2023-10-16" @default.
- W2769151330 title "Genomewide association study of HLA alloimmunization in previously pregnant blood donors" @default.
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- W2769151330 doi "https://doi.org/10.1111/trf.14402" @default.
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