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- W2769245576 abstract "<ns4:p><ns4:bold>Background:</ns4:bold> The effect of beta-blockers on perioperative mortality in non-cardiac surgery has been controversial due to concerns regarding the scientific integrity of the DECREASE-I and DECREASE-IV trials. Previous meta-analyses indicated beta-blockade might increase mortality after removing the DECREASE trials from the evidence base.</ns4:p><ns4:p> <ns4:bold>Methods:</ns4:bold> In this report, we statistically investigate the DECREASE trials and model their veracity (i.e., the probability that these effects or more extreme occurred naturally) and estimate how many data points might have been manipulated in the DECREASE trials using the inversion method.</ns4:p><ns4:p> <ns4:bold>Results:</ns4:bold> Our research indicates that the DECREASE trials are nearly impossible if we assume they investigate the same effect as the non-DECREASE trials and under that assumption. Our results also provide evidence that at least some data points were manipulated.</ns4:p><ns4:p> <ns4:bold>Conclusions:</ns4:bold> The DECREASE trials are likely to be manipulated under the assumption that they investigate the same effect as the non-DECREASE trials on beta-blockade. However, these differences might also be due to different conceptual approaches as to how beta-blockade might prevent mortality in non-cardiac surgery. Considering this, we recommend new and more extensively controlled, confirmatory trials to determine whether there is any use in administering beta-blockers in order to decrease perioperative mortality.</ns4:p>" @default.
- W2769245576 created "2017-12-04" @default.
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- W2769245576 date "2017-11-13" @default.
- W2769245576 modified "2023-09-23" @default.
- W2769245576 title "Analyzing DECREASE trials to estimate evidence of data manipulation" @default.
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- W2769245576 doi "https://doi.org/10.12688/f1000research.12584.1" @default.
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