FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769328964> ?p ?o ?g. }

• W2769328964 abstract "The genus Paracoccidioides comprises known fungal pathogens of humans and can be isolated from different infection sites. Metabolic peculiarities in different members of the Paracoccidioides led us to perform proteomic studies in the presence of the two-carbon molecule acetate, which predominates in the nutrient-poor environment of the phagosome. To investigate the expression rates of proteins of different members of Paracoccidioides, including one isolate of P. lutzii (Pb01) and three isolates of P. brasiliensis (Pb03, Pb339, and PbEPM83), using sodium acetate as a carbon source, proteins were quantified using label-free and data-independent liquid chromatography-mass spectrometry. Protein profiles of the isolates were statistically analyzed, revealing proteins that were differentially expressed when the fungus was cultivated in a non-preferential carbon source rather than glucose. A total of 1160, 1211, 1280, and 1462 proteins were reproducibly identified and relatively quantified in P. lutzii and the P. brasiliensis isolates Pb03, Pb339, and PbEPM83, respectively. Notably, 526, 435, 744, and 747 proteins were differentially expressed among P. lutzii and the P. brasiliensis isolates Pb03, Pb339, and PbEPM83, respectively, with a fold-change equal to or higher than 1.5. This analysis revealed that reorganization of metabolism occurred through the induction of proteins related to gluconeogenesis, glyoxylic/glyoxylate cycle, response to stress, and degradation of amino acids in the four isolates. The following differences were observed among the isolates: higher increases in the expression levels of proteins belonging to the TCA and respiratory chain in PbEPM83 and Pb01; increase in anaerobic metabolism in Pb01; utilization of cell wall components for gluconeogenesis in Pb03 and PbEPM83; and increased β-oxidation and methylcitrate cycle proteins in Pb01and PbEPM83. Proteomic profiles indicated that the four isolates reorganized their metabolism in different manners to use acetate as a carbon source." @default.
• W2769328964 created "2017-12-04" @default.
• W2769328964 creator A5001921795 @default.
• W2769328964 creator A5020136136 @default.
• W2769328964 creator A5027806001 @default.
• W2769328964 creator A5032693800 @default.
• W2769328964 creator A5036400037 @default.
• W2769328964 creator A5038237628 @default.
• W2769328964 creator A5045040370 @default.
• W2769328964 date "2017-11-27" @default.
• W2769328964 modified "2023-09-26" @default.
• W2769328964 title "Differential Metabolism of a Two-Carbon Substrate by Members of the Paracoccidioides Genus" @default.
• W2769328964 cites W1507486726 @default.
• W2769328964 cites W1512648700 @default.
• W2769328964 cites W1545982832 @default.
• W2769328964 cites W1643772983 @default.
• W2769328964 cites W1647692986 @default.
• W2769328964 cites W1687960050 @default.
• W2769328964 cites W1839977438 @default.
• W2769328964 cites W1864461701 @default.
• W2769328964 cites W1943619333 @default.
• W2769328964 cites W1965944807 @default.
• W2769328964 cites W1983730914 @default.
• W2769328964 cites W1996326847 @default.
• W2769328964 cites W1997290272 @default.
• W2769328964 cites W2001389730 @default.
• W2769328964 cites W2007766433 @default.
• W2769328964 cites W2017923988 @default.
• W2769328964 cites W2023022448 @default.
• W2769328964 cites W2028036101 @default.
• W2769328964 cites W2050897300 @default.
• W2769328964 cites W2050964657 @default.
• W2769328964 cites W2053867514 @default.
• W2769328964 cites W2055823541 @default.
• W2769328964 cites W2056171217 @default.
• W2769328964 cites W2057549505 @default.
• W2769328964 cites W2060751499 @default.
• W2769328964 cites W2066138347 @default.
• W2769328964 cites W2068554382 @default.
• W2769328964 cites W2069962303 @default.
• W2769328964 cites W2074863750 @default.
• W2769328964 cites W2075891899 @default.
• W2769328964 cites W2076342526 @default.
• W2769328964 cites W2076464901 @default.
• W2769328964 cites W2078352967 @default.
• W2769328964 cites W2088874499 @default.
• W2769328964 cites W2089021764 @default.
• W2769328964 cites W2096393734 @default.
• W2769328964 cites W2096913845 @default.
• W2769328964 cites W2099117928 @default.
• W2769328964 cites W2105889496 @default.
• W2769328964 cites W2110874942 @default.
• W2769328964 cites W2114950068 @default.
• W2769328964 cites W2125953270 @default.
• W2769328964 cites W2128635872 @default.
• W2769328964 cites W2131942193 @default.
• W2769328964 cites W2140244176 @default.
• W2769328964 cites W2141633133 @default.
• W2769328964 cites W2144627099 @default.
• W2769328964 cites W2154003739 @default.
• W2769328964 cites W2155341933 @default.
• W2769328964 cites W2159253964 @default.
• W2769328964 cites W2168104095 @default.
• W2769328964 cites W2173186713 @default.
• W2769328964 cites W2180879921 @default.
• W2769328964 cites W2294522757 @default.
• W2769328964 cites W2298923917 @default.
• W2769328964 cites W2315775302 @default.
• W2769328964 cites W2483125769 @default.
• W2769328964 cites W2519655322 @default.
• W2769328964 cites W2525892789 @default.
• W2769328964 cites W2559483967 @default.
• W2769328964 cites W2573620119 @default.
• W2769328964 cites W2734723785 @default.
• W2769328964 cites W2736928935 @default.
• W2769328964 cites W4233554622 @default.
• W2769328964 cites W4247088117 @default.
• W2769328964 cites W4293247451 @default.
• W2769328964 cites W63714611 @default.
• W2769328964 doi "https://doi.org/10.3389/fmicb.2017.02308" @default.
• W2769328964 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5711815" @default.
• W2769328964 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29230201" @default.
• W2769328964 hasPublicationYear "2017" @default.
• W2769328964 type Work @default.
• W2769328964 sameAs 2769328964 @default.
• W2769328964 citedByCount "12" @default.
• W2769328964 countsByYear W27693289642019 @default.
• W2769328964 countsByYear W27693289642020 @default.
• W2769328964 countsByYear W27693289642021 @default.
• W2769328964 countsByYear W27693289642023 @default.
• W2769328964 crossrefType "journal-article" @default.
• W2769328964 hasAuthorship W2769328964A5001921795 @default.
• W2769328964 hasAuthorship W2769328964A5020136136 @default.
• W2769328964 hasAuthorship W2769328964A5027806001 @default.
• W2769328964 hasAuthorship W2769328964A5032693800 @default.
• W2769328964 hasAuthorship W2769328964A5036400037 @default.
• W2769328964 hasAuthorship W2769328964A5038237628 @default.
• W2769328964 hasAuthorship W2769328964A5045040370 @default.
• W2769328964 hasBestOaLocation W27693289641 @default.
• W2769328964 hasConcept C165267168 @default.

• next