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- W2769367050 abstract "Direct hydroxymethylation of C=N double bonds including imines, nitrones, oximes, hydrazones and iminium salts is a less explored synthetic approach to 1,2-amino alcohols that provides good alternatives to the classical methods. The review deals with nucleophilic additions of organometallic hydroxymethyl reagents and lithiated alkoxyallenes to C=N double bonds. Reductive cross couplings between C=N double bonds and aldehydes or ketones are also discussed. Keywords: Hydroxymethylation, 1, 2-amino alcohols, imines, nitrones, hydrazones, iminium, reductive cross-couplings." @default.
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- W2769367050 date "2018-04-12" @default.
- W2769367050 modified "2023-10-14" @default.
- W2769367050 title "Direct Hydroxymethylation of C=N Double Bonds" @default.
- W2769367050 doi "https://doi.org/10.2174/1570178614666171121144234" @default.
- W2769367050 hasPublicationYear "2018" @default.
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