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• W2769423727 abstract "Despite a well-established role for the epidermal growth factor receptor (EGFR) in tumorigenesis, EGFR activities and endocytosis in tumors in vivo have not been studied. We labeled endogenous EGFR with GFP by genome-editing of human oral squamous cell carcinoma cells, which were used to examine EGFR-GFP behavior in mouse tumor xenografts in vivo. Intravital multiphoton imaging, confocal imaging of cryosections and biochemical analysis revealed that localization and trafficking patterns, as well as levels of phosphorylation and ubiquitylation of EGFR in tumors in vivo closely resemble patterns and levels observed in the same cells treated with 20–200 pM EGF in vitro. Consistent with the prediction of low ligand concentrations in tumors, EGFR endocytosis was kinase-dependent and blocked by inhibitors of clathrin-mediated internalization; and EGFR activity was insensitive to Cbl overexpression. Collectively, our data suggest that a small pool of active EGFRs is sufficient to drive tumorigenesis by signaling primarily through the Ras-MAPK pathway." @default.
• W2769423727 created "2017-12-04" @default.
• W2769423727 creator A5023401203 @default.
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• W2769423727 creator A5074692336 @default.
• W2769423727 creator A5088924932 @default.
• W2769423727 date "2017-12-21" @default.
• W2769423727 modified "2023-10-18" @default.
• W2769423727 title "EGF receptor signaling, phosphorylation, ubiquitylation and endocytosis in tumors in vivo" @default.
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• W2769423727 doi "https://doi.org/10.7554/elife.31993" @default.
• W2769423727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5741375" @default.
• W2769423727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29268862" @default.
• W2769423727 hasPublicationYear "2017" @default.
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