FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2769432461> ?p ?o ?g. }

• W2769432461 endingPage "60" @default.
• W2769432461 startingPage "55" @default.
• W2769432461 abstract "Environmental stress such as genotoxic agents can cause DNA damage either indirectly through the generation of reactive oxygen species or directly by interactions with the DNA molecule. Damage to the genetic material may cause mutations and ultimately cancer. Genotoxic mutation can be prevented either by apoptosis or DNA repair. In response to DNA damage, cells have evolved DNA damage responses (DDR) to detect, signal, and repair DNA lesions. Epigenetic mechanisms play critically important roles in DDR, which requires changes in chromatin structure and dynamics to modulate DNA accessibility. Incorporation of histone variants into chromatin is considered as an epigenetic mechanism. Canonical histones can be replaced with variant histones that change chromatin structure, stability, and dynamics. Recent studies have demonstrated involvement of nearly all histone variants in environmental-stress-induced DNA damage repair through various mechanisms, including affecting nucleosome dynamics, carrying variant-specific modification, promoting transcriptional competence or silencing, mediating rearrangement of chromosomes, attracting specific repair proteins, among others. In this review, we will focus on the role of histone variants in DNA damage repair after exposure to environmental genotoxic agents. Understanding the mechanisms regulating environmental exposure-induced epigenetic changes, including replacement of canonical histones with histone variants, will promote the development of strategies to prevent or reverse these changes." @default.
• W2769432461 created "2017-12-04" @default.
• W2769432461 creator A5003653900 @default.
• W2769432461 creator A5051064208 @default.
• W2769432461 date "2019-04-01" @default.
• W2769432461 modified "2023-10-16" @default.
• W2769432461 title "Histone variants in environmental-stress-induced DNA damage repair" @default.
• W2769432461 cites W1880656333 @default.
• W2769432461 cites W1963882904 @default.
• W2769432461 cites W1964480889 @default.
• W2769432461 cites W1970469121 @default.
• W2769432461 cites W1974368630 @default.
• W2769432461 cites W1975859486 @default.
• W2769432461 cites W1979210718 @default.
• W2769432461 cites W1983329574 @default.
• W2769432461 cites W1984194102 @default.
• W2769432461 cites W1985775217 @default.
• W2769432461 cites W1986625994 @default.
• W2769432461 cites W1992040448 @default.
• W2769432461 cites W1997313092 @default.
• W2769432461 cites W1999477960 @default.
• W2769432461 cites W2002637963 @default.
• W2769432461 cites W2006001474 @default.
• W2769432461 cites W2007884336 @default.
• W2769432461 cites W2008185037 @default.
• W2769432461 cites W2008686279 @default.
• W2769432461 cites W2010001065 @default.
• W2769432461 cites W2010016604 @default.
• W2769432461 cites W2010817679 @default.
• W2769432461 cites W2012025493 @default.
• W2769432461 cites W2012036589 @default.
• W2769432461 cites W2013472031 @default.
• W2769432461 cites W2015416439 @default.
• W2769432461 cites W2016861729 @default.
• W2769432461 cites W2019637656 @default.
• W2769432461 cites W2025209634 @default.
• W2769432461 cites W2025525406 @default.
• W2769432461 cites W2027111177 @default.
• W2769432461 cites W2031002439 @default.
• W2769432461 cites W2035282314 @default.
• W2769432461 cites W2037231961 @default.
• W2769432461 cites W2041686632 @default.
• W2769432461 cites W2042605756 @default.
• W2769432461 cites W2044524973 @default.
• W2769432461 cites W2048061807 @default.
• W2769432461 cites W2048343533 @default.
• W2769432461 cites W2050445493 @default.
• W2769432461 cites W2054674322 @default.
• W2769432461 cites W2056795443 @default.
• W2769432461 cites W2060439764 @default.
• W2769432461 cites W2061536881 @default.
• W2769432461 cites W2062536956 @default.
• W2769432461 cites W2065288910 @default.
• W2769432461 cites W2068599792 @default.
• W2769432461 cites W2073660843 @default.
• W2769432461 cites W2076684722 @default.
• W2769432461 cites W2082636922 @default.
• W2769432461 cites W2087736976 @default.
• W2769432461 cites W2090759699 @default.
• W2769432461 cites W2097286561 @default.
• W2769432461 cites W2103638977 @default.
• W2769432461 cites W2107308955 @default.
• W2769432461 cites W2113195616 @default.
• W2769432461 cites W2113451554 @default.
• W2769432461 cites W2114404734 @default.
• W2769432461 cites W2114783229 @default.
• W2769432461 cites W2116536643 @default.
• W2769432461 cites W2118466825 @default.
• W2769432461 cites W2118997256 @default.
• W2769432461 cites W2120971578 @default.
• W2769432461 cites W2126563386 @default.
• W2769432461 cites W2131543691 @default.
• W2769432461 cites W2132401124 @default.
• W2769432461 cites W2141897899 @default.
• W2769432461 cites W2144792857 @default.
• W2769432461 cites W2145924925 @default.
• W2769432461 cites W2152385412 @default.
• W2769432461 cites W2162287523 @default.
• W2769432461 cites W2166944445 @default.
• W2769432461 cites W2181359557 @default.
• W2769432461 cites W2525846959 @default.
• W2769432461 cites W266468415 @default.
• W2769432461 cites W2757843220 @default.
• W2769432461 cites W762283860 @default.
• W2769432461 doi "https://doi.org/10.1016/j.mrrev.2017.11.002" @default.
• W2769432461 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6690500" @default.
• W2769432461 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31395349" @default.
• W2769432461 hasPublicationYear "2019" @default.
• W2769432461 type Work @default.
• W2769432461 sameAs 2769432461 @default.
• W2769432461 citedByCount "11" @default.
• W2769432461 countsByYear W27694324612019 @default.
• W2769432461 countsByYear W27694324612020 @default.
• W2769432461 countsByYear W27694324612021 @default.
• W2769432461 countsByYear W27694324612022 @default.
• W2769432461 countsByYear W27694324612023 @default.
• W2769432461 crossrefType "journal-article" @default.
• W2769432461 hasAuthorship W2769432461A5003653900 @default.

• next