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• W2769439495 abstract "Glutamine (Gln) is the most concentrated amino acid in blood and considered conditionally essential. Its requirement is increased during physiological stress, such as malnutrition or illness, despite its production by muscle and other organs. In the malnourished state, Gln has been suggested to have a trophic effect on the exocrine pancreas and small intestine. However, the Gln transport capacity, the functional relationship of these two organs, and the potential role of the Gln-glutamate (Glu) cycle are unknown. We observed that pancreatic acinar cells express lower levels of Glu than Gln transporters. Consistent with this expression pattern, the rate of Glu influx into acinar cells was approximately sixfold lower than that of Gln. During protein restriction, acinar cell glutaminase expression was increased and Gln accumulation was maintained. Moreover, Glu secretion by acinar cells into pancreatic juice and thus into the lumen of the small intestine was maintained. In the intestinal lumen, Glu absorption was preserved and Glu dehydrogenase expression was augmented, potentially providing the substrates for increasing energy production via the TCA cycle. Our findings suggest that one mechanism by which Gln exerts a positive effect on exocrine pancreas and small intestine involves the Gln metabolism in acinar cells and the secretion of Glu into the small intestine lumen. The exocrine pancreas acinar cells not only avidly accumulate Gln but metabolize Gln to generate energy and to synthesize Glu for secretion in the pancreatic juice. Secreted Glu is suggested to play an important role during malnourishment in sustaining small intestinal homeostasis. NEW & NOTEWORTHY Glutamine (Gln) has been suggested to have a trophic effect on exocrine pancreas and small intestine in malnourished states, but the mechanism is unknown. In this study, we suggest that this trophic effect derives from an interorgan relationship between exocrine pancreas and small intestine for Gln-glutamate (Glu) utilization involving the uptake and metabolism of Gln in acinar cells and secretion of Glu into the lumen of the small intestine." @default.
• W2769439495 created "2017-12-04" @default.
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• W2769439495 date "2018-04-01" @default.
• W2769439495 modified "2023-10-16" @default.
• W2769439495 title "Exocrine pancreas glutamate secretion help to sustain enterocyte nutritional needs under protein restriction" @default.
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• W2769439495 cites W1562122315 @default.
• W2769439495 cites W1935980275 @default.
• W2769439495 cites W1966397808 @default.
• W2769439495 cites W1973493429 @default.
• W2769439495 cites W1976712030 @default.
• W2769439495 cites W1986944539 @default.
• W2769439495 cites W1987292751 @default.
• W2769439495 cites W1988970110 @default.
• W2769439495 cites W1990165591 @default.
• W2769439495 cites W1991413218 @default.
• W2769439495 cites W1992962914 @default.
• W2769439495 cites W1993022928 @default.
• W2769439495 cites W1999031023 @default.
• W2769439495 cites W1999046627 @default.
• W2769439495 cites W2014133949 @default.
• W2769439495 cites W2014988241 @default.
• W2769439495 cites W2018040702 @default.
• W2769439495 cites W2019683270 @default.
• W2769439495 cites W2020493113 @default.
• W2769439495 cites W2020838403 @default.
• W2769439495 cites W2024862672 @default.
• W2769439495 cites W2026427702 @default.
• W2769439495 cites W2028686926 @default.
• W2769439495 cites W2032149238 @default.
• W2769439495 cites W2033622898 @default.
• W2769439495 cites W2036103142 @default.
• W2769439495 cites W2038459908 @default.
• W2769439495 cites W2038652783 @default.
• W2769439495 cites W2043735721 @default.
• W2769439495 cites W2047933315 @default.
• W2769439495 cites W2055255976 @default.
• W2769439495 cites W2072933237 @default.
• W2769439495 cites W2074873270 @default.
• W2769439495 cites W2082990697 @default.
• W2769439495 cites W2084912053 @default.
• W2769439495 cites W2086816631 @default.
• W2769439495 cites W2090433349 @default.
• W2769439495 cites W2091547880 @default.
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• W2769439495 cites W2100795125 @default.
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• W2769439495 cites W2113866126 @default.
• W2769439495 cites W2114501709 @default.
• W2769439495 cites W2121440732 @default.
• W2769439495 cites W2121616521 @default.
• W2769439495 cites W2122919189 @default.
• W2769439495 cites W2129513191 @default.
• W2769439495 cites W2136813222 @default.
• W2769439495 cites W2137903553 @default.
• W2769439495 cites W2153829300 @default.
• W2769439495 cites W2153898627 @default.
• W2769439495 cites W2159969455 @default.
• W2769439495 cites W2167661342 @default.
• W2769439495 cites W2211746017 @default.
• W2769439495 cites W2258095947 @default.
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• W2769439495 cites W2269870164 @default.
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• W2769439495 doi "https://doi.org/10.1152/ajpgi.00135.2017" @default.
• W2769439495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29167114" @default.
• W2769439495 hasPublicationYear "2018" @default.
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